Comparative in vitro transmucosal permeation of three proprietary diclofenac gels

Studies to evaluate the clinical efficacy and safety of various topical NSAIDS compared to oral NSAIDS have been reported but little research has been conducted to evaluate the efficacy of topical NSAIDS from different manufacturers containing the same concentation of medicament. The aim of this stu...

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Detalles Bibliográficos
Autores principales:	Tripathi, Poonam, Pandey, Awanish, Pandey, Rishabh D., Pandey, Aditya
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia diclofenac; franz diffusion cell; NSAIDS; permeation Agentes Antiinflamatorios no Esteroides Permeabilidad Vías de Administración de Medicamentos Diclofenaco
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8242 http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_18.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8242
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia diclofenac; franz diffusion cell; NSAIDS; permeation Agentes Antiinflamatorios no Esteroides Permeabilidad Vías de Administración de Medicamentos Diclofenaco
spellingShingle	Farmacia diclofenac; franz diffusion cell; NSAIDS; permeation Agentes Antiinflamatorios no Esteroides Permeabilidad Vías de Administración de Medicamentos Diclofenaco Tripathi, Poonam Pandey, Awanish Pandey, Rishabh D. Pandey, Aditya Comparative in vitro transmucosal permeation of three proprietary diclofenac gels
topic_facet	Farmacia diclofenac; franz diffusion cell; NSAIDS; permeation Agentes Antiinflamatorios no Esteroides Permeabilidad Vías de Administración de Medicamentos Diclofenaco
description	Studies to evaluate the clinical efficacy and safety of various topical NSAIDS compared to oral NSAIDS have been reported but little research has been conducted to evaluate the efficacy of topical NSAIDS from different manufacturers containing the same concentation of medicament. The aim of this study was to make comparison of the in vitro release rate of three proprietary Diclofenac gels. To study the in vitro potential of these formulation permeation studies were performed with Franz diffusion cell by using cellulose acetate membrane. In vitro permeation study was found that the diffusion profile of A gel was equivalent to Voveran Emulgel while B gel was significantly (p < 0.05) lower than Voveran Emulgel. This data indicates that the simple denotation of Diclofenac sodium 1% w/w gel is inadequate as a means of distinguishing between similar formulations of different manufacturers that might contain the same types of excipients. This highlights the potential problems that may arise from the mistaken assumption that generic prescriptions and formulations are pharmaceutically and clinically equivalent and interchangeable
format	Articulo Articulo
author	Tripathi, Poonam Pandey, Awanish Pandey, Rishabh D. Pandey, Aditya
author_facet	Tripathi, Poonam Pandey, Awanish Pandey, Rishabh D. Pandey, Aditya
author_sort	Tripathi, Poonam
title	Comparative in vitro transmucosal permeation of three proprietary diclofenac gels
title_short	Comparative in vitro transmucosal permeation of three proprietary diclofenac gels
title_full	Comparative in vitro transmucosal permeation of three proprietary diclofenac gels
title_fullStr	Comparative in vitro transmucosal permeation of three proprietary diclofenac gels
title_full_unstemmed	Comparative in vitro transmucosal permeation of three proprietary diclofenac gels
title_sort	comparative in vitro transmucosal permeation of three proprietary diclofenac gels
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8242 http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_18.pdf
work_keys_str_mv	AT tripathipoonam comparativeinvitrotransmucosalpermeationofthreeproprietarydiclofenacgels AT pandeyawanish comparativeinvitrotransmucosalpermeationofthreeproprietarydiclofenacgels AT pandeyrishabhd comparativeinvitrotransmucosalpermeationofthreeproprietarydiclofenacgels AT pandeyaditya comparativeinvitrotransmucosalpermeationofthreeproprietarydiclofenacgels
bdutipo_str	Repositorios
_version_	1764820488255700992

Comparative in vitro transmucosal permeation of three proprietary diclofenac gels

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