Characterization and basic guidelines for the quality control of chitosan for drug delivery in pharmaceutical applications

Chitosan is increasingly used as an alternative to synthetic polymers due to its water solubility, biodegradability, and biological activity. In this work, chitosan samples from three suppliers were evaluated and characterized by physicochemical methods in an attempt to analyze pharmaceutical applic...

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Autores principales: Cunha Júnior, Armando S. da, Moura, Edson S., Heneine, Luiz G. D., Faraco, André A.G.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Polisacáridos
biomaterial; biopolymer; characterization; chitosan
Química Farmacéutica
Termodinámica
Rastreo Diferencial de Calorimetría
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8240
http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_16.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8240
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Polisacáridos
biomaterial; biopolymer; characterization; chitosan
Química Farmacéutica
Termodinámica
Rastreo Diferencial de Calorimetría
spellingShingle Farmacia
Polisacáridos
biomaterial; biopolymer; characterization; chitosan
Química Farmacéutica
Termodinámica
Rastreo Diferencial de Calorimetría
Cunha Júnior, Armando S. da
Moura, Edson S.
Heneine, Luiz G. D.
Faraco, André A.G.
Characterization and basic guidelines for the quality control of chitosan for drug delivery in pharmaceutical applications
topic_facet Farmacia
Polisacáridos
biomaterial; biopolymer; characterization; chitosan
Química Farmacéutica
Termodinámica
Rastreo Diferencial de Calorimetría
description Chitosan is increasingly used as an alternative to synthetic polymers due to its water solubility, biodegradability, and biological activity. In this work, chitosan samples from three suppliers were evaluated and characterized by physicochemical methods in an attempt to analyze pharmaceutical applications. The degree of deacetylation (DD) was determined by 1H NMR, IR spectra, potentiometric titration, and UV spectrophotometry. The analysis was supplemented by the techniques of DSC, TG, loss on drying, pH of the suspension, heavy metals, sulphated ash, and triple detector size exclusion chromatography (TriSEC). The use of UV, IR, and 1H NMR techniques to determine the degree of deacetylation, limit testing for heavy metals and sulphated ash to analyze inorganic waste, and TriSEC to analyze molecular weights and molecular distribution are recommended as basic requirements for pharmaceutical applications.
format Articulo
Articulo
author Cunha Júnior, Armando S. da
Moura, Edson S.
Heneine, Luiz G. D.
Faraco, André A.G.
author_facet Cunha Júnior, Armando S. da
Moura, Edson S.
Heneine, Luiz G. D.
Faraco, André A.G.
author_sort Cunha Júnior, Armando S. da
title Characterization and basic guidelines for the quality control of chitosan for drug delivery in pharmaceutical applications
title_short Characterization and basic guidelines for the quality control of chitosan for drug delivery in pharmaceutical applications
title_full Characterization and basic guidelines for the quality control of chitosan for drug delivery in pharmaceutical applications
title_fullStr Characterization and basic guidelines for the quality control of chitosan for drug delivery in pharmaceutical applications
title_full_unstemmed Characterization and basic guidelines for the quality control of chitosan for drug delivery in pharmaceutical applications
title_sort characterization and basic guidelines for the quality control of chitosan for drug delivery in pharmaceutical applications
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8240
http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_16.pdf
work_keys_str_mv AT cunhajuniorarmandosda characterizationandbasicguidelinesforthequalitycontrolofchitosanfordrugdeliveryinpharmaceuticalapplications
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AT heneineluizgd characterizationandbasicguidelinesforthequalitycontrolofchitosanfordrugdeliveryinpharmaceuticalapplications
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