Characterization and basic guidelines for the quality control of chitosan for drug delivery in pharmaceutical applications

Chitosan is increasingly used as an alternative to synthetic polymers due to its water solubility, biodegradability, and biological activity. In this work, chitosan samples from three suppliers were evaluated and characterized by physicochemical methods in an attempt to analyze pharmaceutical applic...

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Detalles Bibliográficos
Autores principales:	Cunha Júnior, Armando S. da, Moura, Edson S., Heneine, Luiz G. D., Faraco, André A.G.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia Polisacáridos biomaterial; biopolymer; characterization; chitosan Química Farmacéutica Termodinámica Rastreo Diferencial de Calorimetría
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8240 http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_16.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Polisacáridos biomaterial; biopolymer; characterization; chitosan Química Farmacéutica Termodinámica Rastreo Diferencial de Calorimetría
spellingShingle	Farmacia Polisacáridos biomaterial; biopolymer; characterization; chitosan Química Farmacéutica Termodinámica Rastreo Diferencial de Calorimetría Cunha Júnior, Armando S. da Moura, Edson S. Heneine, Luiz G. D. Faraco, André A.G. Characterization and basic guidelines for the quality control of chitosan for drug delivery in pharmaceutical applications
topic_facet	Farmacia Polisacáridos biomaterial; biopolymer; characterization; chitosan Química Farmacéutica Termodinámica Rastreo Diferencial de Calorimetría
description	Chitosan is increasingly used as an alternative to synthetic polymers due to its water solubility, biodegradability, and biological activity. In this work, chitosan samples from three suppliers were evaluated and characterized by physicochemical methods in an attempt to analyze pharmaceutical applications. The degree of deacetylation (DD) was determined by 1H NMR, IR spectra, potentiometric titration, and UV spectrophotometry. The analysis was supplemented by the techniques of DSC, TG, loss on drying, pH of the suspension, heavy metals, sulphated ash, and triple detector size exclusion chromatography (TriSEC). The use of UV, IR, and 1H NMR techniques to determine the degree of deacetylation, limit testing for heavy metals and sulphated ash to analyze inorganic waste, and TriSEC to analyze molecular weights and molecular distribution are recommended as basic requirements for pharmaceutical applications.
format	Articulo Articulo
author	Cunha Júnior, Armando S. da Moura, Edson S. Heneine, Luiz G. D. Faraco, André A.G.
author_facet	Cunha Júnior, Armando S. da Moura, Edson S. Heneine, Luiz G. D. Faraco, André A.G.
author_sort	Cunha Júnior, Armando S. da
title	Characterization and basic guidelines for the quality control of chitosan for drug delivery in pharmaceutical applications
title_short	Characterization and basic guidelines for the quality control of chitosan for drug delivery in pharmaceutical applications
title_full	Characterization and basic guidelines for the quality control of chitosan for drug delivery in pharmaceutical applications
title_fullStr	Characterization and basic guidelines for the quality control of chitosan for drug delivery in pharmaceutical applications
title_full_unstemmed	Characterization and basic guidelines for the quality control of chitosan for drug delivery in pharmaceutical applications
title_sort	characterization and basic guidelines for the quality control of chitosan for drug delivery in pharmaceutical applications
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8240 http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_16.pdf
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bdutipo_str	Repositorios
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Characterization and basic guidelines for the quality control of chitosan for drug delivery in pharmaceutical applications

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