Enalapril effects on nitric oxide synthase inhibition-induced hypertension: hemodynamic and oxidative stress evaluations

This study examined the effects of enalapril treatment on L-NAME-induced hypertensive rats and oxidative profile in the heart. Four experimental groups were established: control (received water for three weeks); L-NAME (600 mg/L in drinking for three weeks); enalapril (20 mg/L in drinking two last w...

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Autores principales: Bock, Patrícia M., Araujo, Alex S. R., Belló Klein, Adriane
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Enfermedades Cardiovasculares
antioxidant enzymes; enalapril; hypertension; lipid peroxidation; nitric oxide
Inhibidores de la Enzima Convertidora de Angiotensina
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8236
http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_12.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8236
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Enfermedades Cardiovasculares
antioxidant enzymes; enalapril; hypertension; lipid peroxidation; nitric oxide
Inhibidores de la Enzima Convertidora de Angiotensina
spellingShingle Farmacia
Enfermedades Cardiovasculares
antioxidant enzymes; enalapril; hypertension; lipid peroxidation; nitric oxide
Inhibidores de la Enzima Convertidora de Angiotensina
Bock, Patrícia M.
Araujo, Alex S. R.
Belló Klein, Adriane
Enalapril effects on nitric oxide synthase inhibition-induced hypertension: hemodynamic and oxidative stress evaluations
topic_facet Farmacia
Enfermedades Cardiovasculares
antioxidant enzymes; enalapril; hypertension; lipid peroxidation; nitric oxide
Inhibidores de la Enzima Convertidora de Angiotensina
description This study examined the effects of enalapril treatment on L-NAME-induced hypertensive rats and oxidative profile in the heart. Four experimental groups were established: control (received water for three weeks); L-NAME (600 mg/L in drinking for three weeks); enalapril (20 mg/L in drinking two last weeks); L-NAME + enalapril, treated with L-NAME for one week, and L-NAME plus enalapril in the last two weeks. Arterial blood pressure, lipid peroxidation (TBARS and chemiluminescence-CL), and catalase, superoxide dismutase, glutathione peroxidase, and glutathione-S-transferase activities were evaluated. An increase by 47 % in the arterial blood pressure was observed in L-NAME-treated rats. Hypertension was reduced (9 %) with enalapril. Hypertension increased TBARS (177 %), CL (23 %), and glutathione peroxidase (31 %), this last, reducing by 11 % in L-NAME + enalapril group. Glutathione-Stransferase increased by 46 % in enalapril group. These results suggest that L-NAME administration increased arterial pressure and oxidative stress, indicating glutathione peroxidase as an important antioxidant in this model.
format Articulo
Articulo
author Bock, Patrícia M.
Araujo, Alex S. R.
Belló Klein, Adriane
author_facet Bock, Patrícia M.
Araujo, Alex S. R.
Belló Klein, Adriane
author_sort Bock, Patrícia M.
title Enalapril effects on nitric oxide synthase inhibition-induced hypertension: hemodynamic and oxidative stress evaluations
title_short Enalapril effects on nitric oxide synthase inhibition-induced hypertension: hemodynamic and oxidative stress evaluations
title_full Enalapril effects on nitric oxide synthase inhibition-induced hypertension: hemodynamic and oxidative stress evaluations
title_fullStr Enalapril effects on nitric oxide synthase inhibition-induced hypertension: hemodynamic and oxidative stress evaluations
title_full_unstemmed Enalapril effects on nitric oxide synthase inhibition-induced hypertension: hemodynamic and oxidative stress evaluations
title_sort enalapril effects on nitric oxide synthase inhibition-induced hypertension: hemodynamic and oxidative stress evaluations
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8236
http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_12.pdf
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AT araujoalexsr enalaprileffectsonnitricoxidesynthaseinhibitioninducedhypertensionhemodynamicandoxidativestressevaluations
AT bellokleinadriane enalaprileffectsonnitricoxidesynthaseinhibitioninducedhypertensionhemodynamicandoxidativestressevaluations
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