Time-dependent and concentration -dependent upregulation of carbamazepine efflux transporter: a preliminary assessment from salivary drug monitoring

The aim of the present study was to detect efflux transporter induction at salivary glands. Six healthy volunteers were involved. On the first day subjects received a single carbamazepine (CBZ) dose of 400 mg. Couples of salivary samples (first and second fraction, S1 and S2) were collected througho...

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Detalles Bibliográficos
Autores principales: Maldonado, Cecilia, Fagiolino, Pietro, Vázquez, Marta, Eiraldi, Rosa, Alvariza, Silvana, Bentancur, Camilo, Álvarez, Pablo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Glándulas Salivales
carbamazepine; efflux transporter induction; saliva drug levels
Anticonvulsivantes
Monitoreo de Drogas
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8235
http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_11.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8235
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Glándulas Salivales
carbamazepine; efflux transporter induction; saliva drug levels
Anticonvulsivantes
Monitoreo de Drogas
spellingShingle Farmacia
Glándulas Salivales
carbamazepine; efflux transporter induction; saliva drug levels
Anticonvulsivantes
Monitoreo de Drogas
Maldonado, Cecilia
Fagiolino, Pietro
Vázquez, Marta
Eiraldi, Rosa
Alvariza, Silvana
Bentancur, Camilo
Álvarez, Pablo
Time-dependent and concentration -dependent upregulation of carbamazepine efflux transporter: a preliminary assessment from salivary drug monitoring
topic_facet Farmacia
Glándulas Salivales
carbamazepine; efflux transporter induction; saliva drug levels
Anticonvulsivantes
Monitoreo de Drogas
description The aim of the present study was to detect efflux transporter induction at salivary glands. Six healthy volunteers were involved. On the first day subjects received a single carbamazepine (CBZ) dose of 400 mg. Couples of salivary samples (first and second fraction, S1 and S2) were collected throughout time after dosing. The following 6 days subjects received 200 mg every twelve hours, and morning pre-dose samples were collected.
format Articulo
Articulo
author Maldonado, Cecilia
Fagiolino, Pietro
Vázquez, Marta
Eiraldi, Rosa
Alvariza, Silvana
Bentancur, Camilo
Álvarez, Pablo
author_facet Maldonado, Cecilia
Fagiolino, Pietro
Vázquez, Marta
Eiraldi, Rosa
Alvariza, Silvana
Bentancur, Camilo
Álvarez, Pablo
author_sort Maldonado, Cecilia
title Time-dependent and concentration -dependent upregulation of carbamazepine efflux transporter: a preliminary assessment from salivary drug monitoring
title_short Time-dependent and concentration -dependent upregulation of carbamazepine efflux transporter: a preliminary assessment from salivary drug monitoring
title_full Time-dependent and concentration -dependent upregulation of carbamazepine efflux transporter: a preliminary assessment from salivary drug monitoring
title_fullStr Time-dependent and concentration -dependent upregulation of carbamazepine efflux transporter: a preliminary assessment from salivary drug monitoring
title_full_unstemmed Time-dependent and concentration -dependent upregulation of carbamazepine efflux transporter: a preliminary assessment from salivary drug monitoring
title_sort time-dependent and concentration -dependent upregulation of carbamazepine efflux transporter: a preliminary assessment from salivary drug monitoring
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8235
http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_11.pdf
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