Design, development and in vitro-in vivo study of colon specific fast disintegrating tablet based on time dependent approach

Targeted delivery systems for treatment of Inflammatory bowel disease (IBD) are designed to increase local tissue concentrations of anti-inflammatory drugs from lower doses compared with systemic administration The objective of this study was to formulate and evaluate an oral system designed to achi...

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Detalles Bibliográficos
Autores principales:	Kshirsagar, Sanjay J., Bhalekar, Mangesh R.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia Administración Oral colon targeting; diclofenac sodium; eudragit RSPO; inflammatory bowel disease; superdisintegrant Sistemas de Liberación de Medicamentos Enfermedades del Colon
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8232 http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_8.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8232
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Administración Oral colon targeting; diclofenac sodium; eudragit RSPO; inflammatory bowel disease; superdisintegrant Sistemas de Liberación de Medicamentos Enfermedades del Colon
spellingShingle	Farmacia Administración Oral colon targeting; diclofenac sodium; eudragit RSPO; inflammatory bowel disease; superdisintegrant Sistemas de Liberación de Medicamentos Enfermedades del Colon Kshirsagar, Sanjay J. Bhalekar, Mangesh R. Design, development and in vitro-in vivo study of colon specific fast disintegrating tablet based on time dependent approach
topic_facet	Farmacia Administración Oral colon targeting; diclofenac sodium; eudragit RSPO; inflammatory bowel disease; superdisintegrant Sistemas de Liberación de Medicamentos Enfermedades del Colon
description	Targeted delivery systems for treatment of Inflammatory bowel disease (IBD) are designed to increase local tissue concentrations of anti-inflammatory drugs from lower doses compared with systemic administration The objective of this study was to formulate and evaluate an oral system designed to achieve site specific and instant drug release in colon for effective treatment of IBD based on time dependent approach. The system consists of core tablet containing model drug diclofenac sodium, superdisintegrant sodium starch glycolate, and coated with pH independent polymer Eudragit RSPO to achieve different total percentage weight gain. Drug release studies were carried out using changing pH method. Placebo formulation containing barium sulphate in the tablet was administered to human volunteers for in vivo X-ray studies. In vitro studies revealed that tablet with 5 % coating level release the drug after 5 h lag time corresponding to the colonic region. Tablets with 5 % coating level could maintain their integrity in human volunteers for 5 h, approximating colon arrival time and release the drug instantaneously. Colon targeting and instant drug release for 5 % coating level was due to swellable hydrophilic polymer, which is responsible for a lag phase preceding the onset of release and the immediate release effect of superdisintegrant, It was observed that as coating level increases, lag time also increases. This is because of increased diffusion path length and tortuosity at higher coating levels. In vivo - in vitro study reveals thickness of coating of Eudragit RSPO play an important role in colon delivery and tablet with superdisintegrant and 5 % coating level achieved the desired performance of the colon targeting.
format	Articulo Articulo
author	Kshirsagar, Sanjay J. Bhalekar, Mangesh R.
author_facet	Kshirsagar, Sanjay J. Bhalekar, Mangesh R.
author_sort	Kshirsagar, Sanjay J.
title	Design, development and in vitro-in vivo study of colon specific fast disintegrating tablet based on time dependent approach
title_short	Design, development and in vitro-in vivo study of colon specific fast disintegrating tablet based on time dependent approach
title_full	Design, development and in vitro-in vivo study of colon specific fast disintegrating tablet based on time dependent approach
title_fullStr	Design, development and in vitro-in vivo study of colon specific fast disintegrating tablet based on time dependent approach
title_full_unstemmed	Design, development and in vitro-in vivo study of colon specific fast disintegrating tablet based on time dependent approach
title_sort	design, development and in vitro-in vivo study of colon specific fast disintegrating tablet based on time dependent approach
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8232 http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_8.pdf
work_keys_str_mv	AT kshirsagarsanjayj designdevelopmentandinvitroinvivostudyofcolonspecificfastdisintegratingtabletbasedontimedependentapproach AT bhalekarmangeshr designdevelopmentandinvitroinvivostudyofcolonspecificfastdisintegratingtabletbasedontimedependentapproach
bdutipo_str	Repositorios
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Design, development and in vitro-in vivo study of colon specific fast disintegrating tablet based on time dependent approach

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