Synthesis, characterization and evaluation of the effect of chemical modification of chitosan on drug release

A novel polymer, chemically modified chitosan was synthesized by reacting with hydrochloride salt of 2-aminoethanoyl chloride. Formation of novel chemically modified chitosan was confirmed by FTIR and NMR spectroscopy and by thermal (DSC) and elemental analysis. Acute oral toxicity study was perform...

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Detalles Bibliográficos
Autores principales: Aloorkar, Nagesh H., Bhatia, Manish S.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
acylation; 2-aminoethanoyl chloride; chitosan; drug release
Polisacáridos
Procesos Bioquímicos
Sistemas de Liberación de Medicamentos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8231
http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_7.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8231
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
acylation; 2-aminoethanoyl chloride; chitosan; drug release
Polisacáridos
Procesos Bioquímicos
Sistemas de Liberación de Medicamentos
spellingShingle Farmacia
acylation; 2-aminoethanoyl chloride; chitosan; drug release
Polisacáridos
Procesos Bioquímicos
Sistemas de Liberación de Medicamentos
Aloorkar, Nagesh H.
Bhatia, Manish S.
Synthesis, characterization and evaluation of the effect of chemical modification of chitosan on drug release
topic_facet Farmacia
acylation; 2-aminoethanoyl chloride; chitosan; drug release
Polisacáridos
Procesos Bioquímicos
Sistemas de Liberación de Medicamentos
description A novel polymer, chemically modified chitosan was synthesized by reacting with hydrochloride salt of 2-aminoethanoyl chloride. Formation of novel chemically modified chitosan was confirmed by FTIR and NMR spectroscopy and by thermal (DSC) and elemental analysis. Acute oral toxicity study was performed on modified chitosan to check its safety. Ibuprofen, paracetamol and diclofenac sodium tablets were compressed on a single punch tablet machine using the weight granulation method. The drug release was found to be delayed from the formulations containing chemically modified chitosan. Thus, it could be concluded that the change in the hydrophilic balance and the resultant change in the modulation of swelling of the polymer may retard the drug release from polymer matrices.
format Articulo
Articulo
author Aloorkar, Nagesh H.
Bhatia, Manish S.
author_facet Aloorkar, Nagesh H.
Bhatia, Manish S.
author_sort Aloorkar, Nagesh H.
title Synthesis, characterization and evaluation of the effect of chemical modification of chitosan on drug release
title_short Synthesis, characterization and evaluation of the effect of chemical modification of chitosan on drug release
title_full Synthesis, characterization and evaluation of the effect of chemical modification of chitosan on drug release
title_fullStr Synthesis, characterization and evaluation of the effect of chemical modification of chitosan on drug release
title_full_unstemmed Synthesis, characterization and evaluation of the effect of chemical modification of chitosan on drug release
title_sort synthesis, characterization and evaluation of the effect of chemical modification of chitosan on drug release
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8231
http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_7.pdf
work_keys_str_mv AT aloorkarnageshh synthesischaracterizationandevaluationoftheeffectofchemicalmodificationofchitosanondrugrelease
AT bhatiamanishs synthesischaracterizationandevaluationoftheeffectofchemicalmodificationofchitosanondrugrelease
bdutipo_str Repositorios
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