Physicochemical characterization, molecular modeling, and stability of the resveratrol-cyclodextrin Inclusion complexes
Resveratrol exhibits wide pharmacological activities, such as, anti-oxidant, anti-inflammatory, analgesic, cardio-protective, neuro-protective, chemo-preventive, chemo-therapeutic, and anti-aging. However, its aqueous solubility is very low. This poor aqueous solubility creates huge problems for its...
Guardado en:
| Autores principales: | , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2011
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8230 http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_6.pdf |
| Aporte de: |
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I19-R120-10915-8230 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia physicochemical characterization; cyclodextrin; inclusion complex; resveratrol; solubility Fenómenos Fisicoquímicos Extractos Vegetales |
| spellingShingle |
Farmacia physicochemical characterization; cyclodextrin; inclusion complex; resveratrol; solubility Fenómenos Fisicoquímicos Extractos Vegetales Das, Surajit NG, Ka-Yun Physicochemical characterization, molecular modeling, and stability of the resveratrol-cyclodextrin Inclusion complexes |
| topic_facet |
Farmacia physicochemical characterization; cyclodextrin; inclusion complex; resveratrol; solubility Fenómenos Fisicoquímicos Extractos Vegetales |
| description |
Resveratrol exhibits wide pharmacological activities, such as, anti-oxidant, anti-inflammatory, analgesic, cardio-protective, neuro-protective, chemo-preventive, chemo-therapeutic, and anti-aging. However, its aqueous solubility is very low. This poor aqueous solubility creates huge problems for its delivery. This study aimed to increase aqueous solubility of resveratrol by forming inclusion complexes with cyclodextrin (CD) derivatives, hydroxypropyl-ß-cyclodextrin (HP-ß-CD) and randomly methylated-ß-cyclodextrin (RM-ß-CD). The physicochemical properties of the inclusion complexes (resveratrol-HP-ß-CD and resveratrol-RM-ß-CD) were investigated by UV scan, Fourier transform infrared spectrophotometry, differential scanning calorimetry, and X-ray diffractometry to confirm the complex formation. Stability of
the inclusion complexes were determined in different storage conditions. Molecular modeling served as a supplementary tool to understand the inclusion behavior of the CDs by predicting the inclusion modes and the stoichiometry of the complexes. Although solubility of resveratrol in the simulated physiological fluids were very low, solubility was increased by CDs. RM-ß-CD was superior to HP-ß-CD for solubility enhancement. The combined use of different characterization techniques suggested inclusion complex formation between resveratrol and CDs. Molecular modeling further supported the inclusion complex formation. Stable solution formulations of resveratrol were prepared in this study. |
| format |
Articulo Articulo |
| author |
Das, Surajit NG, Ka-Yun |
| author_facet |
Das, Surajit NG, Ka-Yun |
| author_sort |
Das, Surajit |
| title |
Physicochemical characterization, molecular modeling, and stability of the resveratrol-cyclodextrin Inclusion complexes |
| title_short |
Physicochemical characterization, molecular modeling, and stability of the resveratrol-cyclodextrin Inclusion complexes |
| title_full |
Physicochemical characterization, molecular modeling, and stability of the resveratrol-cyclodextrin Inclusion complexes |
| title_fullStr |
Physicochemical characterization, molecular modeling, and stability of the resveratrol-cyclodextrin Inclusion complexes |
| title_full_unstemmed |
Physicochemical characterization, molecular modeling, and stability of the resveratrol-cyclodextrin Inclusion complexes |
| title_sort |
physicochemical characterization, molecular modeling, and stability of the resveratrol-cyclodextrin inclusion complexes |
| publishDate |
2011 |
| url |
http://sedici.unlp.edu.ar/handle/10915/8230 http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_6.pdf |
| work_keys_str_mv |
AT dassurajit physicochemicalcharacterizationmolecularmodelingandstabilityoftheresveratrolcyclodextrininclusioncomplexes AT ngkayun physicochemicalcharacterizationmolecularmodelingandstabilityoftheresveratrolcyclodextrininclusioncomplexes |
| bdutipo_str |
Repositorios |
| _version_ |
1764820488107851776 |