Free films containing acrylic polymer and B-cyclodextrin as potential material for colonic delivery: permeability, swelling property, and physicochemical analyses

This work evaluated the influence of B-cyclodextrin (B-CD) on Eudragit® FS 30 D (FS) free film-forming capacity in the following blends: 90:10 and 95:5 (FS: B-CD) as material for potential application in colonic drug delivery systems. A control film (FS 100 %) was also prepared. Determination of swe...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Oliveira, Luciana S., Jesus, Liana I., Hechenleitner, Ana A. W., Albuquerque Cavalcanti, Osvaldo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
B-cyclodextrin; eudragit® FS 30 D; free film
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8227
http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_3.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8227
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
B-cyclodextrin; eudragit® FS 30 D; free film
spellingShingle Farmacia
B-cyclodextrin; eudragit® FS 30 D; free film
Oliveira, Luciana S.
Jesus, Liana I.
Hechenleitner, Ana A. W.
Albuquerque Cavalcanti, Osvaldo
Free films containing acrylic polymer and B-cyclodextrin as potential material for colonic delivery: permeability, swelling property, and physicochemical analyses
topic_facet Farmacia
B-cyclodextrin; eudragit® FS 30 D; free film
description This work evaluated the influence of B-cyclodextrin (B-CD) on Eudragit® FS 30 D (FS) free film-forming capacity in the following blends: 90:10 and 95:5 (FS: B-CD) as material for potential application in colonic drug delivery systems. A control film (FS 100 %) was also prepared. Determination of swelling index (Is%) and permeability and physicochemical analysis were carried out. Formulations containing 95:5 or 90:10 FS: B-CD ratio and about 5 % of glyceryl monostearate (GMS) as a glidant provided homogeneous, continuous, and flexible films. Water vapour transmission (WVT) increased with an increase in B-CD concentration. On the other hand, how major was the B-CD amount lower was found the Is% for the film. Physicochemical analysis using TG revealed an initial thermal decomposition temperature shift that indicated lower thermal stability for films with 90:10 or 95:5 FS: B-CD ratio compared with the control (100:0). The results of FT-IR did not give evidence of any intermolecular interaction between B-CD and the acrylic polymer, showing just a physical mixture of both components in formulation.
format Articulo
Articulo
author Oliveira, Luciana S.
Jesus, Liana I.
Hechenleitner, Ana A. W.
Albuquerque Cavalcanti, Osvaldo
author_facet Oliveira, Luciana S.
Jesus, Liana I.
Hechenleitner, Ana A. W.
Albuquerque Cavalcanti, Osvaldo
author_sort Oliveira, Luciana S.
title Free films containing acrylic polymer and B-cyclodextrin as potential material for colonic delivery: permeability, swelling property, and physicochemical analyses
title_short Free films containing acrylic polymer and B-cyclodextrin as potential material for colonic delivery: permeability, swelling property, and physicochemical analyses
title_full Free films containing acrylic polymer and B-cyclodextrin as potential material for colonic delivery: permeability, swelling property, and physicochemical analyses
title_fullStr Free films containing acrylic polymer and B-cyclodextrin as potential material for colonic delivery: permeability, swelling property, and physicochemical analyses
title_full_unstemmed Free films containing acrylic polymer and B-cyclodextrin as potential material for colonic delivery: permeability, swelling property, and physicochemical analyses
title_sort free films containing acrylic polymer and b-cyclodextrin as potential material for colonic delivery: permeability, swelling property, and physicochemical analyses
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8227
http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_3.pdf
work_keys_str_mv AT oliveiralucianas freefilmscontainingacrylicpolymerandbcyclodextrinaspotentialmaterialforcolonicdeliverypermeabilityswellingpropertyandphysicochemicalanalyses
AT jesuslianai freefilmscontainingacrylicpolymerandbcyclodextrinaspotentialmaterialforcolonicdeliverypermeabilityswellingpropertyandphysicochemicalanalyses
AT hechenleitneranaaw freefilmscontainingacrylicpolymerandbcyclodextrinaspotentialmaterialforcolonicdeliverypermeabilityswellingpropertyandphysicochemicalanalyses
AT albuquerquecavalcantiosvaldo freefilmscontainingacrylicpolymerandbcyclodextrinaspotentialmaterialforcolonicdeliverypermeabilityswellingpropertyandphysicochemicalanalyses
bdutipo_str Repositorios
_version_ 1764820488066957317

Ejemplares similares