Design and evaluation of novel emulgel containing acyclovir for herpes simplex keratitis

The objective of the present research was to develop acyclovir ophthalmic emulgels using different polymers such as Pluronic F 127 (PF 127), Gelrite, Carbopol 934P, hydroxypropylmethylcellulose (HPMC K100M) and sodium carboxymethylcellulose (Na CMC). The prepared emulgel formulations were subjected...

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Autores principales: Dixit, Anil S., Charyulu, Narayana, Nayari, Harish
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Polímeros
acyclovir; herpes simplex keratitis; emulgels; pluronic F 127
Agentes Antivirales
Enfermedades Cutáneas Virales
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8226
http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_2.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8226
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Polímeros
acyclovir; herpes simplex keratitis; emulgels; pluronic F 127
Agentes Antivirales
Enfermedades Cutáneas Virales
spellingShingle Farmacia
Polímeros
acyclovir; herpes simplex keratitis; emulgels; pluronic F 127
Agentes Antivirales
Enfermedades Cutáneas Virales
Dixit, Anil S.
Charyulu, Narayana
Nayari, Harish
Design and evaluation of novel emulgel containing acyclovir for herpes simplex keratitis
topic_facet Farmacia
Polímeros
acyclovir; herpes simplex keratitis; emulgels; pluronic F 127
Agentes Antivirales
Enfermedades Cutáneas Virales
description The objective of the present research was to develop acyclovir ophthalmic emulgels using different polymers such as Pluronic F 127 (PF 127), Gelrite, Carbopol 934P, hydroxypropylmethylcellulose (HPMC K100M) and sodium carboxymethylcellulose (Na CMC). The prepared emulgel formulations were subjected for in vitro characterization. All the prepared emulgels showed acceptable physical properties concerning color, homogeneity, consistency, pH value and osmolality. Water absorption studies of formulations containing pluronic F 127 showed lesser water absorption in comparison to other formulations. All the formulations showed shear thinning pseudo plastic behavior. The formulation containing pluronic F 127 of 22 % showed higher viscosity. No significant release difference was observed between in vitro release and ex vivo release using goat cornea. The rate of drug release from all the emulgels was found to be non fickian (anomalous) release. There was no macroscopic evidence of microbial growth in the media; hence it passes the test for sterility. Ocular irritation studies done on rabbits indicated that all formulations were non irritant and did not cause inflammation. Stability studies showed that the prepared emulgels remained unchanged upon storage for 3 months at refrigerated temperature (4-8 °C).
format Articulo
Articulo
author Dixit, Anil S.
Charyulu, Narayana
Nayari, Harish
author_facet Dixit, Anil S.
Charyulu, Narayana
Nayari, Harish
author_sort Dixit, Anil S.
title Design and evaluation of novel emulgel containing acyclovir for herpes simplex keratitis
title_short Design and evaluation of novel emulgel containing acyclovir for herpes simplex keratitis
title_full Design and evaluation of novel emulgel containing acyclovir for herpes simplex keratitis
title_fullStr Design and evaluation of novel emulgel containing acyclovir for herpes simplex keratitis
title_full_unstemmed Design and evaluation of novel emulgel containing acyclovir for herpes simplex keratitis
title_sort design and evaluation of novel emulgel containing acyclovir for herpes simplex keratitis
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8226
http://www.latamjpharm.org/resumenes/30/5/LAJOP_30_5_1_2.pdf
work_keys_str_mv AT dixitanils designandevaluationofnovelemulgelcontainingacyclovirforherpessimplexkeratitis
AT charyulunarayana designandevaluationofnovelemulgelcontainingacyclovirforherpessimplexkeratitis
AT nayariharish designandevaluationofnovelemulgelcontainingacyclovirforherpessimplexkeratitis
bdutipo_str Repositorios
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