Antiinflammatory activity and biochemical parameters of the ethanol extract of Nopalea cochenillifera (L.) Salm-Dyck (Cactaceae)
We evaluated the antiinflammatory activity of ethanol 70 % extract of Nopalea cochenillifera in a model of induction of granulomatous tissue and the kidney and liver toxicity through serum dosage in rats. During 7 days were administered orally 1.5 ml, 3 times a day, of the ethanol extract of clado...
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| Autores principales: | , , , , , |
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| Formato: | Articulo Comunicacion |
| Lenguaje: | Inglés |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8215 http://www.latamjpharm.org/resumenes/30/4/LAJOP_30_4_2_2.pdf |
| Aporte de: |
| Sumario: | We evaluated the antiinflammatory activity of ethanol 70 % extract of Nopalea cochenillifera
in a model of induction of granulomatous tissue and the kidney and liver toxicity through serum dosage in
rats. During 7 days were administered orally 1.5 ml, 3 times a day, of the ethanol extract of cladodes of N.
cochenillifera. We used nimesulide 5 mg/kg/day as positive control and 20 % propylene glycol as a negative
control. After the treatment period, we assessed the formation of granulomas and the serum levels of AST,
ALT, albumin, creatinine and urea in all groups, noting that the animals treated with the extract showed
53.5 % inhibition formation of granulomatous tissue while the positive control group showed 58.5 %, confirming a significant antiinflammatory activity. There was not a significant elevation of biochemical markers in relation to negative control. |
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