Antiinflammatory activity and biochemical parameters of the ethanol extract of Nopalea cochenillifera (L.) Salm-Dyck (Cactaceae)

We evaluated the antiinflammatory activity of ethanol 70 % extract of Nopalea cochenillifera in a model of induction of granulomatous tissue and the kidney and liver toxicity through serum dosage in rats. During 7 days were administered orally 1.5 ml, 3 times a day, of the ethanol extract of clado...

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Autores principales: Necchi, Raquel M.M., Maki, Tiago D.T., Canto, Gizele S. do, Moresco, Rafael N., Dalmora, Sérgio Luiz, Manfron, Melânia Palermo
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
antiinflammatory; granuloma, Nopalea cochenillifera; toxicity
Extractos Vegetales
Granuloma
Experimentación Animal
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8215
http://www.latamjpharm.org/resumenes/30/4/LAJOP_30_4_2_2.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8215
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
antiinflammatory; granuloma, Nopalea cochenillifera; toxicity
Extractos Vegetales
Granuloma
Experimentación Animal
spellingShingle Farmacia
antiinflammatory; granuloma, Nopalea cochenillifera; toxicity
Extractos Vegetales
Granuloma
Experimentación Animal
Necchi, Raquel M.M.
Maki, Tiago D.T.
Canto, Gizele S. do
Moresco, Rafael N.
Dalmora, Sérgio Luiz
Manfron, Melânia Palermo
Antiinflammatory activity and biochemical parameters of the ethanol extract of Nopalea cochenillifera (L.) Salm-Dyck (Cactaceae)
topic_facet Farmacia
antiinflammatory; granuloma, Nopalea cochenillifera; toxicity
Extractos Vegetales
Granuloma
Experimentación Animal
description We evaluated the antiinflammatory activity of ethanol 70 % extract of Nopalea cochenillifera in a model of induction of granulomatous tissue and the kidney and liver toxicity through serum dosage in rats. During 7 days were administered orally 1.5 ml, 3 times a day, of the ethanol extract of cladodes of N. cochenillifera. We used nimesulide 5 mg/kg/day as positive control and 20 % propylene glycol as a negative control. After the treatment period, we assessed the formation of granulomas and the serum levels of AST, ALT, albumin, creatinine and urea in all groups, noting that the animals treated with the extract showed 53.5 % inhibition formation of granulomatous tissue while the positive control group showed 58.5 %, confirming a significant antiinflammatory activity. There was not a significant elevation of biochemical markers in relation to negative control.
format Articulo
Comunicacion
author Necchi, Raquel M.M.
Maki, Tiago D.T.
Canto, Gizele S. do
Moresco, Rafael N.
Dalmora, Sérgio Luiz
Manfron, Melânia Palermo
author_facet Necchi, Raquel M.M.
Maki, Tiago D.T.
Canto, Gizele S. do
Moresco, Rafael N.
Dalmora, Sérgio Luiz
Manfron, Melânia Palermo
author_sort Necchi, Raquel M.M.
title Antiinflammatory activity and biochemical parameters of the ethanol extract of Nopalea cochenillifera (L.) Salm-Dyck (Cactaceae)
title_short Antiinflammatory activity and biochemical parameters of the ethanol extract of Nopalea cochenillifera (L.) Salm-Dyck (Cactaceae)
title_full Antiinflammatory activity and biochemical parameters of the ethanol extract of Nopalea cochenillifera (L.) Salm-Dyck (Cactaceae)
title_fullStr Antiinflammatory activity and biochemical parameters of the ethanol extract of Nopalea cochenillifera (L.) Salm-Dyck (Cactaceae)
title_full_unstemmed Antiinflammatory activity and biochemical parameters of the ethanol extract of Nopalea cochenillifera (L.) Salm-Dyck (Cactaceae)
title_sort antiinflammatory activity and biochemical parameters of the ethanol extract of nopalea cochenillifera (l.) salm-dyck (cactaceae)
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8215
http://www.latamjpharm.org/resumenes/30/4/LAJOP_30_4_2_2.pdf
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