Antibacterial activity of two pregnenolone-derivatives against Vibrio cholerae and Escherichia coli and its relationship with descriptors LogP, Π

In this work the antibacterial activity of two pregnenolone-derivatives was evaluated on V. cholerae and E. coli, using a NCCLS broth dilution modified method. Additionally, to delineate the structural chemical requirements of the steroid derivatives as antibacterial agents on E. coli and V. cholera...

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Detalles Bibliográficos
Autores principales: Figueroa, Lauro, Díaz, Francisco, López, María, Camacho, Abelardo, García, Elodia, Ozaeta, Rolando
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
E. coli; pregnenolone-carbamazepine; pregnenolone-vitamin B1; V. cholerae
Bacterias Gramnegativas
Agentes Antibacterianos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8211
http://www.latamjpharm.org/resumenes/30/4/LAJOP_30_4_1_19.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8211
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
E. coli; pregnenolone-carbamazepine; pregnenolone-vitamin B1; V. cholerae
Bacterias Gramnegativas
Agentes Antibacterianos
spellingShingle Farmacia
E. coli; pregnenolone-carbamazepine; pregnenolone-vitamin B1; V. cholerae
Bacterias Gramnegativas
Agentes Antibacterianos
Figueroa, Lauro
Díaz, Francisco
López, María
Camacho, Abelardo
García, Elodia
Ozaeta, Rolando
Antibacterial activity of two pregnenolone-derivatives against Vibrio cholerae and Escherichia coli and its relationship with descriptors LogP, Π
topic_facet Farmacia
E. coli; pregnenolone-carbamazepine; pregnenolone-vitamin B1; V. cholerae
Bacterias Gramnegativas
Agentes Antibacterianos
description In this work the antibacterial activity of two pregnenolone-derivatives was evaluated on V. cholerae and E. coli, using a NCCLS broth dilution modified method. Additionally, to delineate the structural chemical requirements of the steroid derivatives as antibacterial agents on E. coli and V. cholerae, other parameters such as the physicochemical descriptors LogP and π were calculated. The results obtained indicate that bacterial growth of E. coli and V. cholerae was inhibited with pregnenolone-vitamin B1 (MIC = 6.64. x 10<sup>-4</sup> mmol/mL) and pregnenolone-carbamazepine (MIC = 3.18 x 10<sup>-4</sup> mmol/mL). Other results showed an increase in LogP and π values in the carbamazepine-pregnenolone conjugate with respect to pregnenolone-vitamin B1. These results suggest that antibacterial activity of two pregnenoloneconjugates can depend of the nature of functional groups involved in their chemical structure that seems to be the key required for their antibacterial activity.
format Articulo
Articulo
author Figueroa, Lauro
Díaz, Francisco
López, María
Camacho, Abelardo
García, Elodia
Ozaeta, Rolando
author_facet Figueroa, Lauro
Díaz, Francisco
López, María
Camacho, Abelardo
García, Elodia
Ozaeta, Rolando
author_sort Figueroa, Lauro
title Antibacterial activity of two pregnenolone-derivatives against Vibrio cholerae and Escherichia coli and its relationship with descriptors LogP, Π
title_short Antibacterial activity of two pregnenolone-derivatives against Vibrio cholerae and Escherichia coli and its relationship with descriptors LogP, Π
title_full Antibacterial activity of two pregnenolone-derivatives against Vibrio cholerae and Escherichia coli and its relationship with descriptors LogP, Π
title_fullStr Antibacterial activity of two pregnenolone-derivatives against Vibrio cholerae and Escherichia coli and its relationship with descriptors LogP, Π
title_full_unstemmed Antibacterial activity of two pregnenolone-derivatives against Vibrio cholerae and Escherichia coli and its relationship with descriptors LogP, Π
title_sort antibacterial activity of two pregnenolone-derivatives against vibrio cholerae and escherichia coli and its relationship with descriptors logp, π
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8211
http://www.latamjpharm.org/resumenes/30/4/LAJOP_30_4_1_19.pdf
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