Formulation and evaluation of multilayered matrix tablets of diltiazem hydrochloride

In the present study matrix and multilayered matrix tablets of diltiazem HCl were formulated by using guar gum as matrix core component and cellulose derivative, Sodium Carboxy Methyl Cellulose (SCMC) as barrier layers. Marked difference in dissolution characteristics of D3 and D3L3 was observed and...

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Autores principales: Mangamoori, Lakshmi N., Yamsani, Madhusudan R.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Disolución
controlled release; cellulose derivatives; diltiazem hcl; multilayered matrix tablets
Estabilidad de Medicamentos
Bloqueadores de los Canales de Calcio
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8206
http://www.latamjpharm.org/resumenes/30/4/LAJOP_30_4_1_14.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8206
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Disolución
controlled release; cellulose derivatives; diltiazem hcl; multilayered matrix tablets
Estabilidad de Medicamentos
Bloqueadores de los Canales de Calcio
spellingShingle Farmacia
Disolución
controlled release; cellulose derivatives; diltiazem hcl; multilayered matrix tablets
Estabilidad de Medicamentos
Bloqueadores de los Canales de Calcio
Mangamoori, Lakshmi N.
Yamsani, Madhusudan R.
Formulation and evaluation of multilayered matrix tablets of diltiazem hydrochloride
topic_facet Farmacia
Disolución
controlled release; cellulose derivatives; diltiazem hcl; multilayered matrix tablets
Estabilidad de Medicamentos
Bloqueadores de los Canales de Calcio
description In the present study matrix and multilayered matrix tablets of diltiazem HCl were formulated by using guar gum as matrix core component and cellulose derivative, Sodium Carboxy Methyl Cellulose (SCMC) as barrier layers. Marked difference in dissolution characteristics of D3 and D3L3 was observed and showed a statistically significant difference. The study revealed that the matrix tablets prolonged the release, but predominantly in a first order fashion. Layering with SCMC granules on the matrix core, provided linear drug release with zero order kinetics. Mean dissolution time for D3 and D3L3 were found to be 4.17 h and 16.45 h, while dissolution efficiency decreased, indicating slower drug release. In vivo transit time of the formulation D3L3 shows that it crossed the small intestine at 6 h and retained for longer time in colon at 12 h. FT-IR and DSC studies show there is no drug-excipeints interaction. Stability studies portray that no change either in physical manifestation or in dissolution profile after storage at 40 ± 2 °C/RH 75 ± 5 % for 3 and 6 months.
format Articulo
Articulo
author Mangamoori, Lakshmi N.
Yamsani, Madhusudan R.
author_facet Mangamoori, Lakshmi N.
Yamsani, Madhusudan R.
author_sort Mangamoori, Lakshmi N.
title Formulation and evaluation of multilayered matrix tablets of diltiazem hydrochloride
title_short Formulation and evaluation of multilayered matrix tablets of diltiazem hydrochloride
title_full Formulation and evaluation of multilayered matrix tablets of diltiazem hydrochloride
title_fullStr Formulation and evaluation of multilayered matrix tablets of diltiazem hydrochloride
title_full_unstemmed Formulation and evaluation of multilayered matrix tablets of diltiazem hydrochloride
title_sort formulation and evaluation of multilayered matrix tablets of diltiazem hydrochloride
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8206
http://www.latamjpharm.org/resumenes/30/4/LAJOP_30_4_1_14.pdf
work_keys_str_mv AT mangamoorilakshmin formulationandevaluationofmultilayeredmatrixtabletsofdiltiazemhydrochloride
AT yamsanimadhusudanr formulationandevaluationofmultilayeredmatrixtabletsofdiltiazemhydrochloride
bdutipo_str Repositorios
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