Influence of Croton tiglium seeds on the pharmacokinetics of anthraquinones in Radix et Rhizoma Rhei

In this study, the influence of Croton tiglium seeds on the pharmacokinetic of rhein in Radix et Rhizoma Rhei was performed to elucidate the compatibility relationship of these two herbs. The pharmacokinetics of rhein was studied following oral administration of pure rhein, Radix et Rhizoma Rhei m...

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Detalles Bibliográficos
Autores principales: Zhang, Jingze, Gao, Wenyuan, Ma, Chaoyi, Gao, Ying, Liu, Zhen, Liu, Changxiao, Yang, Liu
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Croton tiglium seeds; Radix et Rhizoma Rhei; rhein; pharmacokinetics
Extractos Vegetales
Fenómenos Bioquímicos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8204
http://www.latamjpharm.org/resumenes/30/4/LAJOP_30_4_1_12.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8204
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Croton tiglium seeds; Radix et Rhizoma Rhei; rhein; pharmacokinetics
Extractos Vegetales
Fenómenos Bioquímicos
spellingShingle Farmacia
Croton tiglium seeds; Radix et Rhizoma Rhei; rhein; pharmacokinetics
Extractos Vegetales
Fenómenos Bioquímicos
Zhang, Jingze
Gao, Wenyuan
Ma, Chaoyi
Gao, Ying
Liu, Zhen
Liu, Changxiao
Yang, Liu
Influence of Croton tiglium seeds on the pharmacokinetics of anthraquinones in Radix et Rhizoma Rhei
topic_facet Farmacia
Croton tiglium seeds; Radix et Rhizoma Rhei; rhein; pharmacokinetics
Extractos Vegetales
Fenómenos Bioquímicos
description In this study, the influence of Croton tiglium seeds on the pharmacokinetic of rhein in Radix et Rhizoma Rhei was performed to elucidate the compatibility relationship of these two herbs. The pharmacokinetics of rhein was studied following oral administration of pure rhein, Radix et Rhizoma Rhei methanol extract (RE) and Radix et Rhizoma Rhei and seeds of Croton tiglium mathanol extract (RCE), with approximately the same dose of 10mg/kg. It was found that comparing with that in monomer, both AUC and C<sub>max</sub> of rhein in RE and different proportion of RCE were significantly different. The results indicated that comparing with the monomer, the concentration of rhein in the plasma was increased in the group of RE whereas the tendency of AUC and C<sub>max</sub> of rhein in RCE presented quite discrepancy depending on the different proportion of RCE.
format Articulo
Articulo
author Zhang, Jingze
Gao, Wenyuan
Ma, Chaoyi
Gao, Ying
Liu, Zhen
Liu, Changxiao
Yang, Liu
author_facet Zhang, Jingze
Gao, Wenyuan
Ma, Chaoyi
Gao, Ying
Liu, Zhen
Liu, Changxiao
Yang, Liu
author_sort Zhang, Jingze
title Influence of Croton tiglium seeds on the pharmacokinetics of anthraquinones in Radix et Rhizoma Rhei
title_short Influence of Croton tiglium seeds on the pharmacokinetics of anthraquinones in Radix et Rhizoma Rhei
title_full Influence of Croton tiglium seeds on the pharmacokinetics of anthraquinones in Radix et Rhizoma Rhei
title_fullStr Influence of Croton tiglium seeds on the pharmacokinetics of anthraquinones in Radix et Rhizoma Rhei
title_full_unstemmed Influence of Croton tiglium seeds on the pharmacokinetics of anthraquinones in Radix et Rhizoma Rhei
title_sort influence of croton tiglium seeds on the pharmacokinetics of anthraquinones in radix et rhizoma rhei
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8204
http://www.latamjpharm.org/resumenes/30/4/LAJOP_30_4_1_12.pdf
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