Antiproliferative effect of extracts and fractions from the calcareous sponge Leucetta aff. floridana from the Colombian Caribbean

Three tumor cell lines of lung (A549), colon (HT29) and breast (MDA-MB-231) were used to evaluate the antiproliferative effect of ethanol and dichloromethane extracts and seven fractions obtained by flash column chromatography from the most bioactive extract of the sponge  Leucetta aff. floridana. E...

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Autores principales: Márquez, Diana M., Thomas, Olivier P., Martínez, Alejandro, Márquez, Edna J.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Plantas Medicinales
antiproliferative activity; fatty acids; Leucetta aff. floridana
Extractos Vegetales
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8200
http://www.latamjpharm.org/resumenes/30/4/LAJOP_30_4_1_8.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8200
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Plantas Medicinales
antiproliferative activity; fatty acids; Leucetta aff. floridana
Extractos Vegetales
spellingShingle Farmacia
Plantas Medicinales
antiproliferative activity; fatty acids; Leucetta aff. floridana
Extractos Vegetales
Márquez, Diana M.
Thomas, Olivier P.
Martínez, Alejandro
Márquez, Edna J.
Antiproliferative effect of extracts and fractions from the calcareous sponge Leucetta aff. floridana from the Colombian Caribbean
topic_facet Farmacia
Plantas Medicinales
antiproliferative activity; fatty acids; Leucetta aff. floridana
Extractos Vegetales
description Three tumor cell lines of lung (A549), colon (HT29) and breast (MDA-MB-231) were used to evaluate the antiproliferative effect of ethanol and dichloromethane extracts and seven fractions obtained by flash column chromatography from the most bioactive extract of the sponge  Leucetta aff. floridana. Ethanol extract showed antiproliferative activity on three cell lines, whereas dichloromethane extract exhibited low activity. Four ethanol fractions showed antiproliferative activity, which was higher on A549 (IC<sub>50</sub> for all four fractions: < 1.0 µg/mL), followed by HT29 ( IC<sub>50</sub> : 2.5 µg/mL; 2.2 µg/mL; 13.2 µg/mL and 15.8 µg/mL) and finally, MDA-MB-231 (IC<sub>50</sub> : 2.8 µg/mL, 8.3 µg/mL; 13.3 µg/mL and 20.5 µg/mL). GCMS analysis of the highest activity fraction permitted to identify sixteen fatty acids among saturated, branched-saturated, monounsaturated and polyunsaturated of which hexadecanoic and hexadecenoic acids were the most abundant fatty acids.
format Articulo
Articulo
author Márquez, Diana M.
Thomas, Olivier P.
Martínez, Alejandro
Márquez, Edna J.
author_facet Márquez, Diana M.
Thomas, Olivier P.
Martínez, Alejandro
Márquez, Edna J.
author_sort Márquez, Diana M.
title Antiproliferative effect of extracts and fractions from the calcareous sponge Leucetta aff. floridana from the Colombian Caribbean
title_short Antiproliferative effect of extracts and fractions from the calcareous sponge Leucetta aff. floridana from the Colombian Caribbean
title_full Antiproliferative effect of extracts and fractions from the calcareous sponge Leucetta aff. floridana from the Colombian Caribbean
title_fullStr Antiproliferative effect of extracts and fractions from the calcareous sponge Leucetta aff. floridana from the Colombian Caribbean
title_full_unstemmed Antiproliferative effect of extracts and fractions from the calcareous sponge Leucetta aff. floridana from the Colombian Caribbean
title_sort antiproliferative effect of extracts and fractions from the calcareous sponge leucetta aff. floridana from the colombian caribbean
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8200
http://www.latamjpharm.org/resumenes/30/4/LAJOP_30_4_1_8.pdf
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