Determination of troxerutin in rabbit plasma by LC-ESI-MS and its application to a pharmacokinetic study

A sensitive and selective liquid chromatography/electrospray mass spectrometry (LC-ESIMS) method for determination of troxerutin in rabbit plasma was developed. After addition of paeoniflorin as internal standard (IS), protein precipitation by methanol: acetonitrile (3:1, v/v) was used as sample pre...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Ma Jianshe, Zhang, Yuqing, Zhang, Meiling, Fan, Xiaofang, Shentu, Yangping, Wang, Xianqin, Wang, Zhibin, Wang, Zhiyi
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2011
Materias:
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8190
http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_2_16.pdf
Aporte de:
id I19-R120-10915-8190
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
LC-ESI-MS; rabbit plasma; troxerutin
Técnicas de Química Analítica
Flavonoles
spellingShingle Farmacia
LC-ESI-MS; rabbit plasma; troxerutin
Técnicas de Química Analítica
Flavonoles
Ma Jianshe
Zhang, Yuqing
Zhang, Meiling
Fan, Xiaofang
Shentu, Yangping
Wang, Xianqin
Wang, Zhibin
Wang, Zhiyi
Determination of troxerutin in rabbit plasma by LC-ESI-MS and its application to a pharmacokinetic study
topic_facet Farmacia
LC-ESI-MS; rabbit plasma; troxerutin
Técnicas de Química Analítica
Flavonoles
description A sensitive and selective liquid chromatography/electrospray mass spectrometry (LC-ESIMS) method for determination of troxerutin in rabbit plasma was developed. After addition of paeoniflorin as internal standard (IS), protein precipitation by methanol: acetonitrile (3:1, v/v) was used as sample preparation. Chromatographic separation was achieved on an Allure (TM) PFP Propyl (2.1 mm × 100 mm, 5 μm) column with methanol-water as mobile phase with gradient elution. Electrospray ionization (ESI) source was applied and operated in positive ion mode; selected ion monitoring (SIM) mode was used to quantification using target fragment ions m/z 765 for troxerutin and m/z 503 for the IS. Calibration plots were linear over the range of 10-5000 ng/mL for troxerutin in rabbit plasma. Lower limit of quantitation (LLOQ) for troxerutin was 10 ng/mL. Mean recovery of troxerutin from plasma was in the range 92.6-98.1 %. RSD of intra-day and inter-day precision were both less than 11 %. This method is simple and sensitive enough to be used in pharmacokinetic research for determination of troxerutin in rabbit plasma.
format Articulo
Comunicacion
author Ma Jianshe
Zhang, Yuqing
Zhang, Meiling
Fan, Xiaofang
Shentu, Yangping
Wang, Xianqin
Wang, Zhibin
Wang, Zhiyi
author_facet Ma Jianshe
Zhang, Yuqing
Zhang, Meiling
Fan, Xiaofang
Shentu, Yangping
Wang, Xianqin
Wang, Zhibin
Wang, Zhiyi
author_sort Ma Jianshe
title Determination of troxerutin in rabbit plasma by LC-ESI-MS and its application to a pharmacokinetic study
title_short Determination of troxerutin in rabbit plasma by LC-ESI-MS and its application to a pharmacokinetic study
title_full Determination of troxerutin in rabbit plasma by LC-ESI-MS and its application to a pharmacokinetic study
title_fullStr Determination of troxerutin in rabbit plasma by LC-ESI-MS and its application to a pharmacokinetic study
title_full_unstemmed Determination of troxerutin in rabbit plasma by LC-ESI-MS and its application to a pharmacokinetic study
title_sort determination of troxerutin in rabbit plasma by lc-esi-ms and its application to a pharmacokinetic study
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8190
http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_2_16.pdf
work_keys_str_mv AT majianshe determinationoftroxerutininrabbitplasmabylcesimsanditsapplicationtoapharmacokineticstudy
AT zhangyuqing determinationoftroxerutininrabbitplasmabylcesimsanditsapplicationtoapharmacokineticstudy
AT zhangmeiling determinationoftroxerutininrabbitplasmabylcesimsanditsapplicationtoapharmacokineticstudy
AT fanxiaofang determinationoftroxerutininrabbitplasmabylcesimsanditsapplicationtoapharmacokineticstudy
AT shentuyangping determinationoftroxerutininrabbitplasmabylcesimsanditsapplicationtoapharmacokineticstudy
AT wangxianqin determinationoftroxerutininrabbitplasmabylcesimsanditsapplicationtoapharmacokineticstudy
AT wangzhibin determinationoftroxerutininrabbitplasmabylcesimsanditsapplicationtoapharmacokineticstudy
AT wangzhiyi determinationoftroxerutininrabbitplasmabylcesimsanditsapplicationtoapharmacokineticstudy
bdutipo_str Repositorios
_version_ 1764820488507359233