Laccase-based biosensor for determination of acetaminophen
The use of biosensors based on laccase is an interesting alternative for monitoring phenolic compounds in pharmaceutical and environmental analysis. The detection and determination of acetaminophen in pharmaceutical samples, using a biosensor with carbon paste modified with laccase is described. The...
Guardado en:
| Autores principales: | , |
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| Formato: | Articulo Comunicacion |
| Lenguaje: | Inglés |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8187 http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_2_13.pdf |
| Aporte de: |
| Sumario: | The use of biosensors based on laccase is an interesting alternative for monitoring phenolic compounds in pharmaceutical and environmental analysis. The detection and determination of acetaminophen in pharmaceutical samples, using a biosensor with carbon paste modified with laccase is described. The method showed good linearity
(r = 0.9954) and low detection and quantification limits (2.4 x 10<sup>-6</sup> mol.L<sup>-1</sup> and 7.9 x 10<sup>-6</sup> mol.L<sup>-1</sup>, respectively). Furthermore, the proposed methodology using an enzyme electrode showed appropriated reproducibility and selectivity. |
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