Pharmacological explanation for medicinal use of St. John's wort in the hypo-motility disorder of gut

St. John's wort (Hypericum perforatum) is widely used in traditional medical system as a laxative agent against gastrointestinal hypo-motility disorders, such as constipation. The present research was carried out to rationalize its therapeutic potential in constipation. St. John's wort aqu...

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Autores principales:	Khan, Arif-ullah, Gilani, Anwarul-Hassan, Khan, Munasib, Subhan, Fazal
Formato:	Articulo Comunicacion
Lenguaje:	Español
Publicado:	2011
Materias:	Farmacia cholinergic; constipation; hypericum perforatum; spasmogenic; St. John's wort Extractos Vegetales Signos y Síntomas Digestivos
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8183 http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_2_9.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Español
topic	Farmacia cholinergic; constipation; hypericum perforatum; spasmogenic; St. John's wort Extractos Vegetales Signos y Síntomas Digestivos
spellingShingle	Farmacia cholinergic; constipation; hypericum perforatum; spasmogenic; St. John's wort Extractos Vegetales Signos y Síntomas Digestivos Khan, Arif-ullah Gilani, Anwarul-Hassan Khan, Munasib Subhan, Fazal Pharmacological explanation for medicinal use of St. John's wort in the hypo-motility disorder of gut
topic_facet	Farmacia cholinergic; constipation; hypericum perforatum; spasmogenic; St. John's wort Extractos Vegetales Signos y Síntomas Digestivos
description	St. John's wort (Hypericum perforatum) is widely used in traditional medical system as a laxative agent against gastrointestinal hypo-motility disorders, such as constipation. The present research was carried out to rationalize its therapeutic potential in constipation. St. John's wort aqueous extract (Sw.Aq), which tested positive for presence of flavonoids, saponins and tannins caused concentration-dependent (1.0-10 mg/mL) contractile effect in the isolated rabbit jejunum preparations. Pretreatment of tissues with atropine (0.1 µM) abolished the stimulatory effect of Sw.Aq, suggesting that the spasmogenic effect of St. John's wort is mediated possibly through muscarinic receptor activation. In the in-vivo studies, Sw.Aq exhibited laxative effect, reflected by increase in number of mice feces. These results indicate that Sw.Aq causes gut stimulation, via cholinergic mechanism and thus provides pharmacological basis for its medicinal use in gut hypo-motility disease, constipation.
format	Articulo Comunicacion
author	Khan, Arif-ullah Gilani, Anwarul-Hassan Khan, Munasib Subhan, Fazal
author_facet	Khan, Arif-ullah Gilani, Anwarul-Hassan Khan, Munasib Subhan, Fazal
author_sort	Khan, Arif-ullah
title	Pharmacological explanation for medicinal use of St. John's wort in the hypo-motility disorder of gut
title_short	Pharmacological explanation for medicinal use of St. John's wort in the hypo-motility disorder of gut
title_full	Pharmacological explanation for medicinal use of St. John's wort in the hypo-motility disorder of gut
title_fullStr	Pharmacological explanation for medicinal use of St. John's wort in the hypo-motility disorder of gut
title_full_unstemmed	Pharmacological explanation for medicinal use of St. John's wort in the hypo-motility disorder of gut
title_sort	pharmacological explanation for medicinal use of st. john's wort in the hypo-motility disorder of gut
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8183 http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_2_9.pdf
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bdutipo_str	Repositorios
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Pharmacological explanation for medicinal use of St. John's wort in the hypo-motility disorder of gut

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