Quantitative structure activity relationship studies of some 5-aryl thiazolidine-2, 4-diones as antidiabetic agents

Quantitative Structure Activity Relationship (QSAR) studies were carried out for a series of 16 compounds which acts as ligands for PPAR-γ receptor. TSAR software was used to identify the essential structural and physicochemical features for their PPAR-γ agonistic activity by performing multiple reg...

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Detalles Bibliográficos
Autores principales:	Sonawane, Lalit V., Bari, Sanjaykumar B.
Formato:	Articulo Comunicacion
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia PPAR-γ receptor; QSAR; thiazolidinedione; TSAR software Análisis Estadístico Tiazoles
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8181 http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_2_6.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8181
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia PPAR-γ receptor; QSAR; thiazolidinedione; TSAR software Análisis Estadístico Tiazoles
spellingShingle	Farmacia PPAR-γ receptor; QSAR; thiazolidinedione; TSAR software Análisis Estadístico Tiazoles Sonawane, Lalit V. Bari, Sanjaykumar B. Quantitative structure activity relationship studies of some 5-aryl thiazolidine-2, 4-diones as antidiabetic agents
topic_facet	Farmacia PPAR-γ receptor; QSAR; thiazolidinedione; TSAR software Análisis Estadístico Tiazoles
description	Quantitative Structure Activity Relationship (QSAR) studies were carried out for a series of 16 compounds which acts as ligands for PPAR-γ receptor. TSAR software was used to identify the essential structural and physicochemical features for their PPAR-γ agonistic activity by performing multiple regression analysis. Significant correlation coefficients (q² = 0.9178) was obtained. The predicted values are in good agreement with the observed activity, suggesting that the model could be useful in the design of novel, more potent PPAR-γ agonist.
format	Articulo Comunicacion
author	Sonawane, Lalit V. Bari, Sanjaykumar B.
author_facet	Sonawane, Lalit V. Bari, Sanjaykumar B.
author_sort	Sonawane, Lalit V.
title	Quantitative structure activity relationship studies of some 5-aryl thiazolidine-2, 4-diones as antidiabetic agents
title_short	Quantitative structure activity relationship studies of some 5-aryl thiazolidine-2, 4-diones as antidiabetic agents
title_full	Quantitative structure activity relationship studies of some 5-aryl thiazolidine-2, 4-diones as antidiabetic agents
title_fullStr	Quantitative structure activity relationship studies of some 5-aryl thiazolidine-2, 4-diones as antidiabetic agents
title_full_unstemmed	Quantitative structure activity relationship studies of some 5-aryl thiazolidine-2, 4-diones as antidiabetic agents
title_sort	quantitative structure activity relationship studies of some 5-aryl thiazolidine-2, 4-diones as antidiabetic agents
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8181 http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_2_6.pdf
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bdutipo_str	Repositorios
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Quantitative structure activity relationship studies of some 5-aryl thiazolidine-2, 4-diones as antidiabetic agents

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