Hepatoprotective activity of Cayratia trifolia (L.) domin against nitrobenzene induced hepatotoxicity

The hepatoprotective activity of ethanolic extract of the whole plant of Cayratia trifolia (L.) Domin was evaluated against nitrobenzene (NB) (50 mg/Kg bw, orally) induced hepatic damage in rats. The extract at the dose of 200 mg/kg body weight were administered orally once every day for 7 success...

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Detalles Bibliográficos
Autores principales:	Guru Kumar, Dugganaboyana, Sonumol, Vattachanakkal M., Rathi, Muthaiyan A., Thirumoorthi, Lakshmanan, Meenakshi, Periasamy, Gopalakrishnan, Velliyur K.
Formato:	Articulo Comunicacion
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia Extractos Vegetales antioxidants; Cayratia trifolia (L.) Domin; histopathology; liver marker enzymes; nitrobenzene
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8176 http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_2_1.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8176
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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Extractos Vegetales antioxidants; Cayratia trifolia (L.) Domin; histopathology; liver marker enzymes; nitrobenzene
spellingShingle	Farmacia Extractos Vegetales antioxidants; Cayratia trifolia (L.) Domin; histopathology; liver marker enzymes; nitrobenzene Guru Kumar, Dugganaboyana Sonumol, Vattachanakkal M. Rathi, Muthaiyan A. Thirumoorthi, Lakshmanan Meenakshi, Periasamy Gopalakrishnan, Velliyur K. Hepatoprotective activity of Cayratia trifolia (L.) domin against nitrobenzene induced hepatotoxicity
topic_facet	Farmacia Extractos Vegetales antioxidants; Cayratia trifolia (L.) Domin; histopathology; liver marker enzymes; nitrobenzene
description	The hepatoprotective activity of ethanolic extract of the whole plant of Cayratia trifolia (L.) Domin was evaluated against nitrobenzene (NB) (50 mg/Kg bw, orally) induced hepatic damage in rats. The extract at the dose of 200 mg/kg body weight were administered orally once every day for 7 successive days. The treatment restores the elevated levels of the liver marker enzymes such as alanine amino transferase, aspartate amino transferase, alkaline phosphatase in serum and lipid peroxidation in tissue homogenate. Whereas the antioxidant enzymes such as superoxide dismutase, catalase and glutathione peroxidase remains decreased in carcinogen induced group and after treatment the levels of antioxidant enzymes increased. Histopathological analysis of the NB induced animals showed severe necrosis and fatty infiltration in liver. After treatment with C. trifolia the rats showed regeneration of hepatocytes. The results thus support the use of C. trifolia as a hepatoprotective agent.
format	Articulo Comunicacion
author	Guru Kumar, Dugganaboyana Sonumol, Vattachanakkal M. Rathi, Muthaiyan A. Thirumoorthi, Lakshmanan Meenakshi, Periasamy Gopalakrishnan, Velliyur K.
author_facet	Guru Kumar, Dugganaboyana Sonumol, Vattachanakkal M. Rathi, Muthaiyan A. Thirumoorthi, Lakshmanan Meenakshi, Periasamy Gopalakrishnan, Velliyur K.
author_sort	Guru Kumar, Dugganaboyana
title	Hepatoprotective activity of Cayratia trifolia (L.) domin against nitrobenzene induced hepatotoxicity
title_short	Hepatoprotective activity of Cayratia trifolia (L.) domin against nitrobenzene induced hepatotoxicity
title_full	Hepatoprotective activity of Cayratia trifolia (L.) domin against nitrobenzene induced hepatotoxicity
title_fullStr	Hepatoprotective activity of Cayratia trifolia (L.) domin against nitrobenzene induced hepatotoxicity
title_full_unstemmed	Hepatoprotective activity of Cayratia trifolia (L.) domin against nitrobenzene induced hepatotoxicity
title_sort	hepatoprotective activity of cayratia trifolia (l.) domin against nitrobenzene induced hepatotoxicity
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8176 http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_2_1.pdf
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Hepatoprotective activity of Cayratia trifolia (L.) domin against nitrobenzene induced hepatotoxicity

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