Effect of pH, vehicles and chemical enhancers on the skin permeation of loratadine

The objective of this work was to investigate feasibility of transdermal delivery of loratadine. Effect of pH, vehicles and chemical enhancers on the skin permeation of loratadine was studied in vitro, using rat abdominal skin as a barrier. In the permeation studies, horizontal 2-chamber diffusion c...

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Autores principales: Li, Zhen, Hao, Tangna, Ding, Pingtian, Mei, Lin, Gao, Dongyan, Liu, Kexin, Tian, Yan, Li, Lei, Tian, Ge
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
loratadine; in vitro permeation; l-menthol; borneol; ethanol
Vías de Administración de Medicamentos
Alergia e Inmunología
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8174
http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_1_18.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8174
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
loratadine; in vitro permeation; l-menthol; borneol; ethanol
Vías de Administración de Medicamentos
Alergia e Inmunología
spellingShingle Farmacia
loratadine; in vitro permeation; l-menthol; borneol; ethanol
Vías de Administración de Medicamentos
Alergia e Inmunología
Li, Zhen
Hao, Tangna
Ding, Pingtian
Mei, Lin
Gao, Dongyan
Liu, Kexin
Tian, Yan
Li, Lei
Tian, Ge
Effect of pH, vehicles and chemical enhancers on the skin permeation of loratadine
topic_facet Farmacia
loratadine; in vitro permeation; l-menthol; borneol; ethanol
Vías de Administración de Medicamentos
Alergia e Inmunología
description The objective of this work was to investigate feasibility of transdermal delivery of loratadine. Effect of pH, vehicles and chemical enhancers on the skin permeation of loratadine was studied in vitro, using rat abdominal skin as a barrier. In the permeation studies, horizontal 2-chamber diffusion cells were used. The amount of loratadine transferred through the skin into the receptor solution, 30 % ethanolsaline solution (v/v), was determined at a predetermined time intervals for 8 h using a high performance chromatography (HPLC). The results showed that transdermal transport of loratadine was not significantly affected by pH. 30 % ethanol-saline solution in donor chamber was more effective than 40 % PGsaline solution in deliverying loratadine in vitro. Among the permeation enhancers (azone, oleic acid, menthol, and borneol) examined, l-menthol and borneol showed the greatest enhancing effect using ethanol as a solvent. Overall, these findings allow a rational approach for designing an effective loratadine transdermal delivery system, it is worth carrying out further investigations.
format Articulo
Articulo
author Li, Zhen
Hao, Tangna
Ding, Pingtian
Mei, Lin
Gao, Dongyan
Liu, Kexin
Tian, Yan
Li, Lei
Tian, Ge
author_facet Li, Zhen
Hao, Tangna
Ding, Pingtian
Mei, Lin
Gao, Dongyan
Liu, Kexin
Tian, Yan
Li, Lei
Tian, Ge
author_sort Li, Zhen
title Effect of pH, vehicles and chemical enhancers on the skin permeation of loratadine
title_short Effect of pH, vehicles and chemical enhancers on the skin permeation of loratadine
title_full Effect of pH, vehicles and chemical enhancers on the skin permeation of loratadine
title_fullStr Effect of pH, vehicles and chemical enhancers on the skin permeation of loratadine
title_full_unstemmed Effect of pH, vehicles and chemical enhancers on the skin permeation of loratadine
title_sort effect of ph, vehicles and chemical enhancers on the skin permeation of loratadine
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8174
http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_1_18.pdf
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