Biotransformation of rhizoma Paridis saponins by rat intestinal microflora

Rhizoma Paridis saponins (RPS) were considered to be the principal bioactive components of Paris polyphylla Smith var. yunnanensis. Intestinal microflora-mediated metabolism may affect their pharmacological activities in vivo. In this study, the biotransformation of RPS by rat intestinal microflora...

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Detalles Bibliográficos
Autores principales:	Liu, Yang, Gao, Wenyuan, Man, Shuli, Ma, Chaoyi, Zhang, Jingze, Liu, Changxiao
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia Técnicas de Química Analítica biotransformation; HPLC-ESI-MS; intestinal microflora; rhizoma Paridis; saponin Procesos Farmacológicos
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8167 http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_1_11.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Técnicas de Química Analítica biotransformation; HPLC-ESI-MS; intestinal microflora; rhizoma Paridis; saponin Procesos Farmacológicos
spellingShingle	Farmacia Técnicas de Química Analítica biotransformation; HPLC-ESI-MS; intestinal microflora; rhizoma Paridis; saponin Procesos Farmacológicos Liu, Yang Gao, Wenyuan Man, Shuli Ma, Chaoyi Zhang, Jingze Liu, Changxiao Biotransformation of rhizoma Paridis saponins by rat intestinal microflora
topic_facet	Farmacia Técnicas de Química Analítica biotransformation; HPLC-ESI-MS; intestinal microflora; rhizoma Paridis; saponin Procesos Farmacológicos
description	Rhizoma Paridis saponins (RPS) were considered to be the principal bioactive components of Paris polyphylla Smith var. yunnanensis. Intestinal microflora-mediated metabolism may affect their pharmacological activities in vivo. In this study, the biotransformation of RPS by rat intestinal microflora in vitro was investigated. A high-performance liquid chromatography with electrospray ionization combined with mass spectrometry (HPLC-ESI-MS) method was developed to identify RPS and their metabolites. The metabolism of RPS by rat intestinal microflora was mainly based on cleavage of the oligosaccharide chains which is connected to the C-3 or C-22 position. However, the elimination of the glucose molecule at C-26 and F-ring closure occurred firstly in prototype saponins. In addition, the biotransformation routes of RPS in the presence of rat intestinal microflora were elaborated, from which RPS were presumed primarily responsible for the metabolism via α-rhamnosidase and β-glycosidase activities. These results would contribute to understanding of the mechanisms in bioavailability of herbal drugs and their metabolites.
format	Articulo Articulo
author	Liu, Yang Gao, Wenyuan Man, Shuli Ma, Chaoyi Zhang, Jingze Liu, Changxiao
author_facet	Liu, Yang Gao, Wenyuan Man, Shuli Ma, Chaoyi Zhang, Jingze Liu, Changxiao
author_sort	Liu, Yang
title	Biotransformation of rhizoma Paridis saponins by rat intestinal microflora
title_short	Biotransformation of rhizoma Paridis saponins by rat intestinal microflora
title_full	Biotransformation of rhizoma Paridis saponins by rat intestinal microflora
title_fullStr	Biotransformation of rhizoma Paridis saponins by rat intestinal microflora
title_full_unstemmed	Biotransformation of rhizoma Paridis saponins by rat intestinal microflora
title_sort	biotransformation of rhizoma paridis saponins by rat intestinal microflora
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8167 http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_1_11.pdf
work_keys_str_mv	AT liuyang biotransformationofrhizomaparidissaponinsbyratintestinalmicroflora AT gaowenyuan biotransformationofrhizomaparidissaponinsbyratintestinalmicroflora AT manshuli biotransformationofrhizomaparidissaponinsbyratintestinalmicroflora AT machaoyi biotransformationofrhizomaparidissaponinsbyratintestinalmicroflora AT zhangjingze biotransformationofrhizomaparidissaponinsbyratintestinalmicroflora AT liuchangxiao biotransformationofrhizomaparidissaponinsbyratintestinalmicroflora
bdutipo_str	Repositorios
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Biotransformation of rhizoma Paridis saponins by rat intestinal microflora

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