Hypromelose / polyethylene oxide (PEO) matrix tablets for oral sustained Aacyclovir release: formulation aspects and release behavior

Hydrophilic matrix tablets were developed with acyclovir (ACV), using hypromelose and polyethylene oxide (PEO) in different concentrations. Matrix tablets obtained in each formulation were evaluated to determine the weight variation, thickness, hardness, drug content, swelling and erosion and in vit...

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Autores principales:	Vechia, Débora D., Barboza, Fernanda M., Beltrame, Flávio L., Fraga, Carlos A., Silva, Marcos A. S., Stulzer, Hellen Karine
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia ACV; hypromelose; hydrophilic matrix tablets; POE; polymer gels
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8166 http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_1_10.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8166
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia ACV; hypromelose; hydrophilic matrix tablets; POE; polymer gels
spellingShingle	Farmacia ACV; hypromelose; hydrophilic matrix tablets; POE; polymer gels Vechia, Débora D. Barboza, Fernanda M. Beltrame, Flávio L. Fraga, Carlos A. Silva, Marcos A. S. Stulzer, Hellen Karine Hypromelose / polyethylene oxide (PEO) matrix tablets for oral sustained Aacyclovir release: formulation aspects and release behavior
topic_facet	Farmacia ACV; hypromelose; hydrophilic matrix tablets; POE; polymer gels
description	Hydrophilic matrix tablets were developed with acyclovir (ACV), using hypromelose and polyethylene oxide (PEO) in different concentrations. Matrix tablets obtained in each formulation were evaluated to determine the weight variation, thickness, hardness, drug content, swelling and erosion and in vitro release. The swelling and erosion studies were influenced by pH value and polymer type. The ACV release under acid conditions occurred around 12 and 6 h for PEO and hypromelose matrices, respectively. The mechanism involved in drug release was characterized by anomalous behavior for all formulations, except in 0.1 N HCl where formulations containing hypromelose demonstrated a Super Case II kinetics.
format	Articulo Articulo
author	Vechia, Débora D. Barboza, Fernanda M. Beltrame, Flávio L. Fraga, Carlos A. Silva, Marcos A. S. Stulzer, Hellen Karine
author_facet	Vechia, Débora D. Barboza, Fernanda M. Beltrame, Flávio L. Fraga, Carlos A. Silva, Marcos A. S. Stulzer, Hellen Karine
author_sort	Vechia, Débora D.
title	Hypromelose / polyethylene oxide (PEO) matrix tablets for oral sustained Aacyclovir release: formulation aspects and release behavior
title_short	Hypromelose / polyethylene oxide (PEO) matrix tablets for oral sustained Aacyclovir release: formulation aspects and release behavior
title_full	Hypromelose / polyethylene oxide (PEO) matrix tablets for oral sustained Aacyclovir release: formulation aspects and release behavior
title_fullStr	Hypromelose / polyethylene oxide (PEO) matrix tablets for oral sustained Aacyclovir release: formulation aspects and release behavior
title_full_unstemmed	Hypromelose / polyethylene oxide (PEO) matrix tablets for oral sustained Aacyclovir release: formulation aspects and release behavior
title_sort	hypromelose / polyethylene oxide (peo) matrix tablets for oral sustained aacyclovir release: formulation aspects and release behavior
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8166 http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_1_10.pdf
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bdutipo_str	Repositorios
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Hypromelose / polyethylene oxide (PEO) matrix tablets for oral sustained Aacyclovir release: formulation aspects and release behavior

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