Design of polymeric prodrugs of ibuprofen using dextran: synthesis, hydrolytic behaviour, pharmacological and antigenicity studies
An N-acyl imidazole derivative of ibuprofen was condensed with a biodegradable polymer dextran 10,000 and 20,000 to obtain ibuprofen-dextran prodrugs IB10 and IB20, respectively. Synthesis and characterization of these prodrugs were carried out with an aim to improve the aqueous solubility, therapeu...
Guardado en:
| Autores principales: | Rasheed, Arun, Sagar, Puletipalli, Saipriya, Kotthapalli, Priyanka, Bheema, Saravana Kumar, Arumugam |
|---|---|
| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2011
|
| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8165 http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_1_9.pdf |
| Aporte de: |
Ejemplares similares
-
Prodrug design of NSAIDs: synthesis and pharmacological profiles of amide prodrugs of etodolac with amino acids
por: Rasheed, Arun, et al.
Publicado: (2011) -
In vitro and in vivo release studies of fluorouracil acetic acid-dextran conjugates
por: Hao, Aijun, et al.
Publicado: (2011) -
Preparation, crystal structure and prodrug studies of genistein benzensulfonate
por: Peng, You, et al.
Publicado: (2011) -
High concentrations of sodium chloride improve microbicidal activity of ibuprofen against common cystic fibrosis pathogens
por: Muñoz, Adrián, et al.
Publicado: (2023) -
Synthesis, Crystal Structure and Prodrug Studies of Daidzein Sulfonate
por: Peng, You, et al.
Publicado: (2012)