Design of polymeric prodrugs of ibuprofen using dextran: synthesis, hydrolytic behaviour, pharmacological and antigenicity studies

An N-acyl imidazole derivative of ibuprofen was condensed with a biodegradable polymer dextran 10,000 and 20,000 to obtain ibuprofen-dextran prodrugs IB10 and IB20, respectively. Synthesis and characterization of these prodrugs were carried out with an aim to improve the aqueous solubility, therapeu...

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Autores principales:	Rasheed, Arun, Sagar, Puletipalli, Saipriya, Kotthapalli, Priyanka, Bheema, Saravana Kumar, Arumugam
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia anti-inflammatory activity; antigenicity; dextran; ibuprofen; polymeric prodrug
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8165 http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_1_9.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8165
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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia anti-inflammatory activity; antigenicity; dextran; ibuprofen; polymeric prodrug
spellingShingle	Farmacia anti-inflammatory activity; antigenicity; dextran; ibuprofen; polymeric prodrug Rasheed, Arun Sagar, Puletipalli Saipriya, Kotthapalli Priyanka, Bheema Saravana Kumar, Arumugam Design of polymeric prodrugs of ibuprofen using dextran: synthesis, hydrolytic behaviour, pharmacological and antigenicity studies
topic_facet	Farmacia anti-inflammatory activity; antigenicity; dextran; ibuprofen; polymeric prodrug
description	An N-acyl imidazole derivative of ibuprofen was condensed with a biodegradable polymer dextran 10,000 and 20,000 to obtain ibuprofen-dextran prodrugs IB10 and IB20, respectively. Synthesis and characterization of these prodrugs were carried out with an aim to improve the aqueous solubility, therapeutic efficiency and to reduce gastrointestinal side effects. IR and NMR studies confirmed the formation of ester linkage. In vitro hydrolysis carried out in SGF, SIF and SCF showed a faster hydrolysis in SIF and SCF. The hydrolysis followed first order kinetics. The prodrugs showed better anti-inflammatory and analgesic activities and remarkable reduction in ulcerogenicity when compared with the parent drug. The prodrugs showed no antigenicity under the conditions used and the dose levels of prodrug employed in the present study were confirmed not to suppress the immune reactions. The results thus proved that dextran can be employed as a promoiety for efficient drug delivery.
format	Articulo Articulo
author	Rasheed, Arun Sagar, Puletipalli Saipriya, Kotthapalli Priyanka, Bheema Saravana Kumar, Arumugam
author_facet	Rasheed, Arun Sagar, Puletipalli Saipriya, Kotthapalli Priyanka, Bheema Saravana Kumar, Arumugam
author_sort	Rasheed, Arun
title	Design of polymeric prodrugs of ibuprofen using dextran: synthesis, hydrolytic behaviour, pharmacological and antigenicity studies
title_short	Design of polymeric prodrugs of ibuprofen using dextran: synthesis, hydrolytic behaviour, pharmacological and antigenicity studies
title_full	Design of polymeric prodrugs of ibuprofen using dextran: synthesis, hydrolytic behaviour, pharmacological and antigenicity studies
title_fullStr	Design of polymeric prodrugs of ibuprofen using dextran: synthesis, hydrolytic behaviour, pharmacological and antigenicity studies
title_full_unstemmed	Design of polymeric prodrugs of ibuprofen using dextran: synthesis, hydrolytic behaviour, pharmacological and antigenicity studies
title_sort	design of polymeric prodrugs of ibuprofen using dextran: synthesis, hydrolytic behaviour, pharmacological and antigenicity studies
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8165 http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_1_9.pdf
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Design of polymeric prodrugs of ibuprofen using dextran: synthesis, hydrolytic behaviour, pharmacological and antigenicity studies

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