Preparation and evaluation of lithium carbonate loaded PEA microspheres for controlled drug delivery

The goal of any drug delivery system is to provide a therapeutic amount of drug (s) to the proper site in the body in order to promptly achieve and there by to maintain the desired drug concentrations during treatment. This idealized objective can be achieved by targeting the drugs to a specific org...

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Detalles Bibliográficos
Autores principales: Malure, Manjunath, Laxmikanthia, Jagdish R, Vishakant, Gowda D., Khan, Mohammed S.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
controlled release; lithium carbonate; microspheres; PEA polymer
Sistemas de Liberación de Medicamentos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8162
http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_1_6.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8162
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
controlled release; lithium carbonate; microspheres; PEA polymer
Sistemas de Liberación de Medicamentos
spellingShingle Farmacia
controlled release; lithium carbonate; microspheres; PEA polymer
Sistemas de Liberación de Medicamentos
Malure, Manjunath
Laxmikanthia, Jagdish R
Vishakant, Gowda D.
Khan, Mohammed S.
Preparation and evaluation of lithium carbonate loaded PEA microspheres for controlled drug delivery
topic_facet Farmacia
controlled release; lithium carbonate; microspheres; PEA polymer
Sistemas de Liberación de Medicamentos
description The goal of any drug delivery system is to provide a therapeutic amount of drug (s) to the proper site in the body in order to promptly achieve and there by to maintain the desired drug concentrations during treatment. This idealized objective can be achieved by targeting the drugs to a specific organ or tissue with the help of controlling the release rate of the drug during the transit time in gastro intestinal tract. Poorly water-soluble drugs, which are lipophilic in nature easily, mix with PEA polymer and show good absorption rate. The PEA polymeric materials used in the current study have good pharmaceutical and biological properties; water is used to prepare PEA polymer microspheres by meltable dispersed emulsified cooling induced solidification method. Surface morphology of prepared microspheres has been evaluated using scanning electron microscopy (SEM). The SEM images revealed the spherical shape of microspheres with size ranges 339 µm to 357 µm. Differential scanning calorimetry and Fourier transform infrared spectroscopy studies indicated that the drug after encapsulation with PEA polymer was stable and compatible.
format Articulo
Articulo
author Malure, Manjunath
Laxmikanthia, Jagdish R
Vishakant, Gowda D.
Khan, Mohammed S.
author_facet Malure, Manjunath
Laxmikanthia, Jagdish R
Vishakant, Gowda D.
Khan, Mohammed S.
author_sort Malure, Manjunath
title Preparation and evaluation of lithium carbonate loaded PEA microspheres for controlled drug delivery
title_short Preparation and evaluation of lithium carbonate loaded PEA microspheres for controlled drug delivery
title_full Preparation and evaluation of lithium carbonate loaded PEA microspheres for controlled drug delivery
title_fullStr Preparation and evaluation of lithium carbonate loaded PEA microspheres for controlled drug delivery
title_full_unstemmed Preparation and evaluation of lithium carbonate loaded PEA microspheres for controlled drug delivery
title_sort preparation and evaluation of lithium carbonate loaded pea microspheres for controlled drug delivery
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8162
http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_1_6.pdf
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AT vishakantgowdad preparationandevaluationoflithiumcarbonateloadedpeamicrospheresforcontrolleddrugdelivery
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