Synthesis, anti-inflammatory and analgesic activity of 4-(substituted benzylamino)-5-substituted phenyl-3-amino-1,2,4-triazole derivatives

A novel series of 4-(substituted benzylamino)-5-substituted phenyl-3-amino-1, 2, 4-triazole derivatives were synthesized by reaction of 5-substituted phenyl-3,4-diamino-1,2,4-triazole with different aromatic aldehydes. The structures of the compounds were synthesized and characterised by elemental a...

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Autores principales: Gangarapu, Kiran, Malothi, Rajkumar, Gudipati, Rajyalakshmi, Jupalli, Venkateshw R., Manda, Sarangapani
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
1, 2, 4 triazole; anti-inflammatory activity; analgesic activity; carrageenan; writhing
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8161
http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_1_5.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8161
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
1, 2, 4 triazole; anti-inflammatory activity; analgesic activity; carrageenan; writhing
spellingShingle Farmacia
1, 2, 4 triazole; anti-inflammatory activity; analgesic activity; carrageenan; writhing
Gangarapu, Kiran
Malothi, Rajkumar
Gudipati, Rajyalakshmi
Jupalli, Venkateshw R.
Manda, Sarangapani
Synthesis, anti-inflammatory and analgesic activity of 4-(substituted benzylamino)-5-substituted phenyl-3-amino-1,2,4-triazole derivatives
topic_facet Farmacia
1, 2, 4 triazole; anti-inflammatory activity; analgesic activity; carrageenan; writhing
description A novel series of 4-(substituted benzylamino)-5-substituted phenyl-3-amino-1, 2, 4-triazole derivatives were synthesized by reaction of 5-substituted phenyl-3,4-diamino-1,2,4-triazole with different aromatic aldehydes. The structures of the compounds were synthesized and characterised by elemental analysis, 1H NMR, Mass and IR Spectra. The title compounds were investigated for anti-inflammatory and analgesic activities using carrageenan induced rat paw edema and acetic induced writhing test, respectively. All the test compounds exhibited significant activity, compounds IVg, IVh and IVb showed more potent anti-inflammatory activity when compared with standard (Ibuprofen). All the test compounds were significantly (p < 0.05) reduced writhings induced by the acetic acid in mice.
format Articulo
Articulo
author Gangarapu, Kiran
Malothi, Rajkumar
Gudipati, Rajyalakshmi
Jupalli, Venkateshw R.
Manda, Sarangapani
author_facet Gangarapu, Kiran
Malothi, Rajkumar
Gudipati, Rajyalakshmi
Jupalli, Venkateshw R.
Manda, Sarangapani
author_sort Gangarapu, Kiran
title Synthesis, anti-inflammatory and analgesic activity of 4-(substituted benzylamino)-5-substituted phenyl-3-amino-1,2,4-triazole derivatives
title_short Synthesis, anti-inflammatory and analgesic activity of 4-(substituted benzylamino)-5-substituted phenyl-3-amino-1,2,4-triazole derivatives
title_full Synthesis, anti-inflammatory and analgesic activity of 4-(substituted benzylamino)-5-substituted phenyl-3-amino-1,2,4-triazole derivatives
title_fullStr Synthesis, anti-inflammatory and analgesic activity of 4-(substituted benzylamino)-5-substituted phenyl-3-amino-1,2,4-triazole derivatives
title_full_unstemmed Synthesis, anti-inflammatory and analgesic activity of 4-(substituted benzylamino)-5-substituted phenyl-3-amino-1,2,4-triazole derivatives
title_sort synthesis, anti-inflammatory and analgesic activity of 4-(substituted benzylamino)-5-substituted phenyl-3-amino-1,2,4-triazole derivatives
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8161
http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_1_5.pdf
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bdutipo_str Repositorios
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