Evaluation of antioxidant and anti-ulcerative potential of Citrullus lanatus seed extract in rats

In the present study antioxidant and antiulcer potential of Citrullus lanatus seeds were evaluated. Antioxidant activity of all the extracts (chloroform, ethylacetate and methanol) was measured by DPPH method. Methanolic extract of Citrullus lanatus (MECL) seeds showed maximum antioxidant potential...

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Autores principales: Singh Gill, Naresh, Sood, Shailja, Muthuraman, Arunachalam, Bali, Manoj, Dev Sharma, Pritam
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Extractos Vegetales
antioxidant; citrullus lanatus; peptic ulcer
Antioxidantes
Agentes Antiulcerosos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8158
http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_1_2.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8158
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Extractos Vegetales
antioxidant; citrullus lanatus; peptic ulcer
Antioxidantes
Agentes Antiulcerosos
spellingShingle Farmacia
Extractos Vegetales
antioxidant; citrullus lanatus; peptic ulcer
Antioxidantes
Agentes Antiulcerosos
Singh Gill, Naresh
Sood, Shailja
Muthuraman, Arunachalam
Bali, Manoj
Dev Sharma, Pritam
Evaluation of antioxidant and anti-ulcerative potential of Citrullus lanatus seed extract in rats
topic_facet Farmacia
Extractos Vegetales
antioxidant; citrullus lanatus; peptic ulcer
Antioxidantes
Agentes Antiulcerosos
description In the present study antioxidant and antiulcer potential of Citrullus lanatus seeds were evaluated. Antioxidant activity of all the extracts (chloroform, ethylacetate and methanol) was measured by DPPH method. Methanolic extract of Citrullus lanatus (MECL) seeds showed maximum antioxidant potential and was evaluated for its anti-ulcerogenic activity by pyloric ligated (PL) and water immersion stress (WIS) induced ulcer models in rat. Gastric volume and free and total acidity were measured in PL model whereas; ulcerative index was measured in both the models at 100, 200 and 300 mg/kg doses of MECL. Rats treated with MECL (300 mg/kg) showed significant decrease in the gastric volume, free acidity and total acidity in case of PL model and showed significant percentage inhibition of ulcer as indicated by decrease in ulcerative index in both the models. The extract of Citrullus lanatus seeds possesses good antioxidant and anti-ulcer activity.
format Articulo
Articulo
author Singh Gill, Naresh
Sood, Shailja
Muthuraman, Arunachalam
Bali, Manoj
Dev Sharma, Pritam
author_facet Singh Gill, Naresh
Sood, Shailja
Muthuraman, Arunachalam
Bali, Manoj
Dev Sharma, Pritam
author_sort Singh Gill, Naresh
title Evaluation of antioxidant and anti-ulcerative potential of Citrullus lanatus seed extract in rats
title_short Evaluation of antioxidant and anti-ulcerative potential of Citrullus lanatus seed extract in rats
title_full Evaluation of antioxidant and anti-ulcerative potential of Citrullus lanatus seed extract in rats
title_fullStr Evaluation of antioxidant and anti-ulcerative potential of Citrullus lanatus seed extract in rats
title_full_unstemmed Evaluation of antioxidant and anti-ulcerative potential of Citrullus lanatus seed extract in rats
title_sort evaluation of antioxidant and anti-ulcerative potential of citrullus lanatus seed extract in rats
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8158
http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_1_2.pdf
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