Comparative functionality of Croscarmellose and Carmacel as tablet excipients

The great variety of excipients to which we have access thanks the globalization gives rise to the necessity to evaluate their functionality, currently the pharmaceutical performance of croscarmellose and carmacel as tablet excipient. Carmacel formulations show faster powder flow and dissolution rat...

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Detalles Bibliográficos
Autores principales: Díaz Ramírez, Carmen C., Villafuerte Robles, Leopoldo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Preparaciones Farmacéuticas
Carmacel; Croscarmellose; excipients functionality; sodium cross-linked carboxymethylcellulose; solid dosage forms; tablet disintegrants
Excipientes Farmacéuticos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8157
http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_1_1.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8157
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Preparaciones Farmacéuticas
Carmacel; Croscarmellose; excipients functionality; sodium cross-linked carboxymethylcellulose; solid dosage forms; tablet disintegrants
Excipientes Farmacéuticos
spellingShingle Farmacia
Preparaciones Farmacéuticas
Carmacel; Croscarmellose; excipients functionality; sodium cross-linked carboxymethylcellulose; solid dosage forms; tablet disintegrants
Excipientes Farmacéuticos
Díaz Ramírez, Carmen C.
Villafuerte Robles, Leopoldo
Comparative functionality of Croscarmellose and Carmacel as tablet excipients
topic_facet Farmacia
Preparaciones Farmacéuticas
Carmacel; Croscarmellose; excipients functionality; sodium cross-linked carboxymethylcellulose; solid dosage forms; tablet disintegrants
Excipientes Farmacéuticos
description The great variety of excipients to which we have access thanks the globalization gives rise to the necessity to evaluate their functionality, currently the pharmaceutical performance of croscarmellose and carmacel as tablet excipient. Carmacel formulations show faster powder flow and dissolution rate while Croscarmellose formulations show greater compactibility. Individually, carmacel formulations show greater powder flow and faster dissolution rate when the diluent is pharmatose or calcium phosphate but if the diluent is alfacel formulations with croscarmellose or carmacel show similar powder flow and dissolution rate. The compactibility of formulations containing pharmatose or calcium phosphate is similar for tablets containing carmacel or croscarmellose while croscarmellose formulations containing alfacel exhibit a greater compactibility. The functionality of croscarmellose and carmacel depends on the parameter and the formulation being considered. Current results are not contradictory with surrogate functionality tests where compactibility of croscarmellose tablets was greater while carmacel tablets showed shorter disintegrations times. the formulation being considered. Current results are not contradictory with surrogate functionality tests where compactibility of croscarmellose tablets was greater while carmacel tablets showed shorter disintegrations times.
format Articulo
Articulo
author Díaz Ramírez, Carmen C.
Villafuerte Robles, Leopoldo
author_facet Díaz Ramírez, Carmen C.
Villafuerte Robles, Leopoldo
author_sort Díaz Ramírez, Carmen C.
title Comparative functionality of Croscarmellose and Carmacel as tablet excipients
title_short Comparative functionality of Croscarmellose and Carmacel as tablet excipients
title_full Comparative functionality of Croscarmellose and Carmacel as tablet excipients
title_fullStr Comparative functionality of Croscarmellose and Carmacel as tablet excipients
title_full_unstemmed Comparative functionality of Croscarmellose and Carmacel as tablet excipients
title_sort comparative functionality of croscarmellose and carmacel as tablet excipients
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8157
http://www.latamjpharm.org/resumenes/30/3/LAJOP_30_3_1_1.pdf
work_keys_str_mv AT diazramirezcarmenc comparativefunctionalityofcroscarmelloseandcarmacelastabletexcipients
AT villafuerteroblesleopoldo comparativefunctionalityofcroscarmelloseandcarmacelastabletexcipients
bdutipo_str Repositorios
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