Effect of monocrotaline on blood-brain barrier permeability in rats

We studied if monocrotaline (MCT) portal hypertensive model modifies blood-brain barrier (BBB) condition. Male Wistar rats were used: Group MCT injected i.p. with MCT (60 mg/kg of body weight) and Group Sham (GS) with saline. Forty-four days after injection rats were sacrificed. Trypan blue and Evan...

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Autores principales: Coll, Carlos, Fernández, María Alejandra, Coll, Sebastián, Coll, Tamara, Malliardi, Pablo, Perazzo, Juan, Filinger, Ester Julia, Lemberg, Abraham
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
blood-brain barrier; liver damag; monocrotaline; portal hypertension
Alcaloides
Técnicas y Procedimientos Diagnósticos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8156
http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_2_13.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8156
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
blood-brain barrier; liver damag; monocrotaline; portal hypertension
Alcaloides
Técnicas y Procedimientos Diagnósticos
spellingShingle Farmacia
blood-brain barrier; liver damag; monocrotaline; portal hypertension
Alcaloides
Técnicas y Procedimientos Diagnósticos
Coll, Carlos
Fernández, María Alejandra
Coll, Sebastián
Coll, Tamara
Malliardi, Pablo
Perazzo, Juan
Filinger, Ester Julia
Lemberg, Abraham
Effect of monocrotaline on blood-brain barrier permeability in rats
topic_facet Farmacia
blood-brain barrier; liver damag; monocrotaline; portal hypertension
Alcaloides
Técnicas y Procedimientos Diagnósticos
description We studied if monocrotaline (MCT) portal hypertensive model modifies blood-brain barrier (BBB) condition. Male Wistar rats were used: Group MCT injected i.p. with MCT (60 mg/kg of body weight) and Group Sham (GS) with saline. Forty-four days after injection rats were sacrificed. Trypan blue and Evans blue tests were performed to evaluate BBB integrity in both groups. In cerebrospinal fluid (CF), protein and glucose were determined. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (AP) were measured in serum samples. Portal pressure rose after MCT injection. Trypan blue diffused into hippocampus, Evans blue increased concentrations in brain of Group MCT and CF showed an increase in protein and glucose content in Group MCT. Serum AST, ALT and AP activities were significantly increased in Group MCT rats. It is suggested that liver damage and vasoconstrictor substances could produce portal hypertension, associated to toxic effects on brain and modifying thereby the BBB permeability.
format Articulo
Comunicacion
author Coll, Carlos
Fernández, María Alejandra
Coll, Sebastián
Coll, Tamara
Malliardi, Pablo
Perazzo, Juan
Filinger, Ester Julia
Lemberg, Abraham
author_facet Coll, Carlos
Fernández, María Alejandra
Coll, Sebastián
Coll, Tamara
Malliardi, Pablo
Perazzo, Juan
Filinger, Ester Julia
Lemberg, Abraham
author_sort Coll, Carlos
title Effect of monocrotaline on blood-brain barrier permeability in rats
title_short Effect of monocrotaline on blood-brain barrier permeability in rats
title_full Effect of monocrotaline on blood-brain barrier permeability in rats
title_fullStr Effect of monocrotaline on blood-brain barrier permeability in rats
title_full_unstemmed Effect of monocrotaline on blood-brain barrier permeability in rats
title_sort effect of monocrotaline on blood-brain barrier permeability in rats
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8156
http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_2_13.pdf
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