Docking studies of few substituted 5-benzyl-2, 4-thiazolidinedione with PPAR-γ for antidiabetic activity

Docking studies of few substituted 5-benzyl-2, 4-thiazolidinedione moiety, which acts as peroxisome proliferator-activated receptor γ agonist was performed by using Glide v4.5. The docking studies reveal hydrogen bond formation to Thr241 with Gscore -7.22 and energy -62.2 kcal/mole. We found hydroge...

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Detalles Bibliográficos
Autores principales: Sonawane, Lalit V., Bari, Sanjaykumar B.
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
docking; glide; PPAR-γ rosiglitazone; thiazolidinedione
Tiazoles
Técnicas de Química Analítica
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8155
http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_2_12.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8155
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
docking; glide; PPAR-γ rosiglitazone; thiazolidinedione
Tiazoles
Técnicas de Química Analítica
docking; glide; PPAR-γ rosiglitazone; thiazolidinedione
spellingShingle Farmacia
docking; glide; PPAR-γ rosiglitazone; thiazolidinedione
Tiazoles
Técnicas de Química Analítica
docking; glide; PPAR-γ rosiglitazone; thiazolidinedione
Sonawane, Lalit V.
Bari, Sanjaykumar B.
Docking studies of few substituted 5-benzyl-2, 4-thiazolidinedione with PPAR-γ for antidiabetic activity
topic_facet Farmacia
docking; glide; PPAR-γ rosiglitazone; thiazolidinedione
Tiazoles
Técnicas de Química Analítica
docking; glide; PPAR-γ rosiglitazone; thiazolidinedione
description Docking studies of few substituted 5-benzyl-2, 4-thiazolidinedione moiety, which acts as peroxisome proliferator-activated receptor γ agonist was performed by using Glide v4.5. The docking studies reveal hydrogen bond formation to Thr241 with Gscore -7.22 and energy -62.2 kcal/mole. We found hydrogen bond formation of most of compounds with good Gscore and low energy as compared to the most active rosiglitazone.
format Articulo
Comunicacion
author Sonawane, Lalit V.
Bari, Sanjaykumar B.
author_facet Sonawane, Lalit V.
Bari, Sanjaykumar B.
author_sort Sonawane, Lalit V.
title Docking studies of few substituted 5-benzyl-2, 4-thiazolidinedione with PPAR-γ for antidiabetic activity
title_short Docking studies of few substituted 5-benzyl-2, 4-thiazolidinedione with PPAR-γ for antidiabetic activity
title_full Docking studies of few substituted 5-benzyl-2, 4-thiazolidinedione with PPAR-γ for antidiabetic activity
title_fullStr Docking studies of few substituted 5-benzyl-2, 4-thiazolidinedione with PPAR-γ for antidiabetic activity
title_full_unstemmed Docking studies of few substituted 5-benzyl-2, 4-thiazolidinedione with PPAR-γ for antidiabetic activity
title_sort docking studies of few substituted 5-benzyl-2, 4-thiazolidinedione with ppar-γ for antidiabetic activity
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8155
http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_2_12.pdf
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