Cardioprotective effect of rutin considering cardiac enzyme level in induced myocardial infarction

The present study was designed to investigate effects of rutin on isoproterenol induced myocardial infarction (MI) by considering enzyme level in rats. Rats were treated with rutin contineously for 10 days (10 mg/kg/day, i.p.,); MI were induced by treating rats with isoproterenol for last 2 consecut...

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Autores principales: Malaviya, Shailesh, Bhalodia, Yagnik, Vaghasiya, Jitendra, Manek, Ravi, Sheth, Navinchandra, Jivani, Nurudin
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
glutathione; malonylaldehyde; myocardial infarction; protein kinase C; rutin; superoxide dismutase
Cardiopatías
Péptidos
Técnicas y Procedimientos de Laboratorio
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8153
http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_2_10.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8153
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
glutathione; malonylaldehyde; myocardial infarction; protein kinase C; rutin; superoxide dismutase
Cardiopatías
Péptidos
Técnicas y Procedimientos de Laboratorio
spellingShingle Farmacia
glutathione; malonylaldehyde; myocardial infarction; protein kinase C; rutin; superoxide dismutase
Cardiopatías
Péptidos
Técnicas y Procedimientos de Laboratorio
Malaviya, Shailesh
Bhalodia, Yagnik
Vaghasiya, Jitendra
Manek, Ravi
Sheth, Navinchandra
Jivani, Nurudin
Cardioprotective effect of rutin considering cardiac enzyme level in induced myocardial infarction
topic_facet Farmacia
glutathione; malonylaldehyde; myocardial infarction; protein kinase C; rutin; superoxide dismutase
Cardiopatías
Péptidos
Técnicas y Procedimientos de Laboratorio
description The present study was designed to investigate effects of rutin on isoproterenol induced myocardial infarction (MI) by considering enzyme level in rats. Rats were treated with rutin contineously for 10 days (10 mg/kg/day, i.p.,); MI were induced by treating rats with isoproterenol for last 2 consecutive days (5.25 and 8 mg/kg, i.p). Protein kinase C (PKC), malonylaldehyde (MAL), Glutathione (GSH), superoxide dismutase (SOD) and survival rate were evaluated. Rutin enhanced survival rate evaluated at the end of experiment. Result shows significant decrease in level of PKC (P < 0.001) and MAL enzyme (P < 0.01) while elevation of GSH (P < 0.001) and SOD (P < 0.001) level in pretreated rutin + isoproterenol group and pretreated rutin group as compared to isoproterenol treated group indicates cardioprotective effect of rutin. The results indicate that Rutin significantly reduces myocardial infarction and emphasize the beneficial action in prevention of MI.
format Articulo
Comunicacion
author Malaviya, Shailesh
Bhalodia, Yagnik
Vaghasiya, Jitendra
Manek, Ravi
Sheth, Navinchandra
Jivani, Nurudin
author_facet Malaviya, Shailesh
Bhalodia, Yagnik
Vaghasiya, Jitendra
Manek, Ravi
Sheth, Navinchandra
Jivani, Nurudin
author_sort Malaviya, Shailesh
title Cardioprotective effect of rutin considering cardiac enzyme level in induced myocardial infarction
title_short Cardioprotective effect of rutin considering cardiac enzyme level in induced myocardial infarction
title_full Cardioprotective effect of rutin considering cardiac enzyme level in induced myocardial infarction
title_fullStr Cardioprotective effect of rutin considering cardiac enzyme level in induced myocardial infarction
title_full_unstemmed Cardioprotective effect of rutin considering cardiac enzyme level in induced myocardial infarction
title_sort cardioprotective effect of rutin considering cardiac enzyme level in induced myocardial infarction
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8153
http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_2_10.pdf
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bdutipo_str Repositorios
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