Syntheses and antimicrobial activities of 2, 3-disubstituted-4-thiazolidinone derivatives
Ten new 4-thiazolidinone derivatives have been synthesized from the alkanoic acids. Alkanoic acid hydrazides (I) on refluxing with aromatic aldehydes in the presence of a catalytic amount of glacial acetic acid in methanol furnish corresponding hydrazones (II). Thioglycolic acid react with (II) in m...
Guardado en:
| Autores principales: | , , |
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| Formato: | Articulo Comunicacion |
| Lenguaje: | Inglés |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8151 http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_2_8.pdf |
| Aporte de: |
| id |
I19-R120-10915-8151 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia Técnicas de Química Analítica antimicrobial activity; synthesis; 4-thiazolidinone |
| spellingShingle |
Farmacia Técnicas de Química Analítica antimicrobial activity; synthesis; 4-thiazolidinone Kumar, Mahesh Jain, Sandeep Deep, Aakash Syntheses and antimicrobial activities of 2, 3-disubstituted-4-thiazolidinone derivatives |
| topic_facet |
Farmacia Técnicas de Química Analítica antimicrobial activity; synthesis; 4-thiazolidinone |
| description |
Ten new 4-thiazolidinone derivatives have been synthesized from the alkanoic acids. Alkanoic acid hydrazides (I) on refluxing with aromatic aldehydes in the presence of a catalytic amount of glacial acetic acid in methanol furnish corresponding hydrazones (II). Thioglycolic acid react with (II) in methanol yield the title compounds (III). These 4-thiazolidinone derivatives were characterized by CHN analysis, IR and 1H NMR spectral data. All the compounds were evaluated for their in vitro antimicrobial activity against two Gram negative strains (Escherichia coli and Pseudomonas aeruginosa) and two Gram positive strains (Bacillus subtilis and Staphylococcus aureus) and fungal strain Candida albicans and Aspergillus niger. All newly synthesized compounds exhibited promising results. |
| format |
Articulo Comunicacion |
| author |
Kumar, Mahesh Jain, Sandeep Deep, Aakash |
| author_facet |
Kumar, Mahesh Jain, Sandeep Deep, Aakash |
| author_sort |
Kumar, Mahesh |
| title |
Syntheses and antimicrobial activities of
2, 3-disubstituted-4-thiazolidinone derivatives |
| title_short |
Syntheses and antimicrobial activities of
2, 3-disubstituted-4-thiazolidinone derivatives |
| title_full |
Syntheses and antimicrobial activities of
2, 3-disubstituted-4-thiazolidinone derivatives |
| title_fullStr |
Syntheses and antimicrobial activities of
2, 3-disubstituted-4-thiazolidinone derivatives |
| title_full_unstemmed |
Syntheses and antimicrobial activities of
2, 3-disubstituted-4-thiazolidinone derivatives |
| title_sort |
syntheses and antimicrobial activities of
2, 3-disubstituted-4-thiazolidinone derivatives |
| publishDate |
2011 |
| url |
http://sedici.unlp.edu.ar/handle/10915/8151 http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_2_8.pdf |
| work_keys_str_mv |
AT kumarmahesh synthesesandantimicrobialactivitiesof23disubstituted4thiazolidinonederivatives AT jainsandeep synthesesandantimicrobialactivitiesof23disubstituted4thiazolidinonederivatives AT deepaakash synthesesandantimicrobialactivitiesof23disubstituted4thiazolidinonederivatives |
| bdutipo_str |
Repositorios |
| _version_ |
1764820488161329154 |