Effects of oral treatment (60 Days) with D-004, a lipid extract from Roystonea regia fruits, on rat prostate hyperplasia and oxidative markers

Short-term (14 days) treatment with D-004, a lipid extract from Roystonea regia fruits, has been shown to prevent testosterone (T)-induced prostate hyperplasia (PH) and increased oxidative stress in rat prostate, but no study has documented if such effects persist after longer treatment. This stud...

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Autores principales: Oyarzábal, Ambar, Jiménez, Sonia, Curveco, Dayisell, Pérez, Yohani, Molina, Vivian, Más, Rosa
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Efectos fisiológicos de las drogas
Extractos Vegetales
D-004; prostatic hyperplasia; oxidative markers; roystonea regia; testosterone
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8147
http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_2_4.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8147
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Efectos fisiológicos de las drogas
Extractos Vegetales
D-004; prostatic hyperplasia; oxidative markers; roystonea regia; testosterone
spellingShingle Farmacia
Efectos fisiológicos de las drogas
Extractos Vegetales
D-004; prostatic hyperplasia; oxidative markers; roystonea regia; testosterone
Oyarzábal, Ambar
Jiménez, Sonia
Curveco, Dayisell
Pérez, Yohani
Molina, Vivian
Más, Rosa
Effects of oral treatment (60 Days) with D-004, a lipid extract from Roystonea regia fruits, on rat prostate hyperplasia and oxidative markers
topic_facet Farmacia
Efectos fisiológicos de las drogas
Extractos Vegetales
D-004; prostatic hyperplasia; oxidative markers; roystonea regia; testosterone
description Short-term (14 days) treatment with D-004, a lipid extract from Roystonea regia fruits, has been shown to prevent testosterone (T)-induced prostate hyperplasia (PH) and increased oxidative stress in rat prostate, but no study has documented if such effects persist after longer treatment. This study investigated the persistence of the effects of D-004 orally given for 60 days for preventing prostate enlargement and increase of oxidative markers in rats with T-induced PH. Rats were randomized into three groups: a negative control and two T-injected that received orally vehicle (positive control) or D-004 (400 mg/kg/day), respectively. Prostate weights of positive controls significantly and markedly increased over the time, while persistent and significant reductions of such increases were seen in D-004-treated rats. Also, D-004 significantly reduced the T-induced increase of prostate conjugated diene generation and sulphydril groups concentrations, achieving a complete reduction from the day 30 after starting the treatment. Concluding, the effects of oral treatment with D-004 (400 mg/kg/day) on T-induced prostate enlargement and increased prostate oxidative markers persisted over 60 days of treatment.
format Articulo
Comunicacion
author Oyarzábal, Ambar
Jiménez, Sonia
Curveco, Dayisell
Pérez, Yohani
Molina, Vivian
Más, Rosa
author_facet Oyarzábal, Ambar
Jiménez, Sonia
Curveco, Dayisell
Pérez, Yohani
Molina, Vivian
Más, Rosa
author_sort Oyarzábal, Ambar
title Effects of oral treatment (60 Days) with D-004, a lipid extract from Roystonea regia fruits, on rat prostate hyperplasia and oxidative markers
title_short Effects of oral treatment (60 Days) with D-004, a lipid extract from Roystonea regia fruits, on rat prostate hyperplasia and oxidative markers
title_full Effects of oral treatment (60 Days) with D-004, a lipid extract from Roystonea regia fruits, on rat prostate hyperplasia and oxidative markers
title_fullStr Effects of oral treatment (60 Days) with D-004, a lipid extract from Roystonea regia fruits, on rat prostate hyperplasia and oxidative markers
title_full_unstemmed Effects of oral treatment (60 Days) with D-004, a lipid extract from Roystonea regia fruits, on rat prostate hyperplasia and oxidative markers
title_sort effects of oral treatment (60 days) with d-004, a lipid extract from roystonea regia fruits, on rat prostate hyperplasia and oxidative markers
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8147
http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_2_4.pdf
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