Anti-anaphylactic and mast cell stabilizing effect of <i>Calotropis gigantea</i> extract
Calotropis gigantea (Linn.) R.Br. (Asclepiadaceae), commonly known as milkweed or swallow- wort, is found chiefly in wasteland throughout India. It has been reported as a traditional folkloric medicine in treatment of asthma in the Indian literature. Roots containing α-and β-amyrin are reported to p...
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| Autores principales: | , , , , |
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| Formato: | Articulo Comunicacion |
| Lenguaje: | Inglés |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8146 http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_2_3.pdf |
| Aporte de: |
| id |
I19-R120-10915-8146 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia asthm calotropis gigantea compound 48/80 mast cells Plantas Medicinales Técnicas y Procedimientos de Laboratorio |
| spellingShingle |
Farmacia asthm calotropis gigantea compound 48/80 mast cells Plantas Medicinales Técnicas y Procedimientos de Laboratorio Bulani, Vipin D. Ghaisas, Mahesh M. Kumar, Dinesh Sarda, Anupama P. Bhamre, Sachin S. Anti-anaphylactic and mast cell stabilizing effect of <i>Calotropis gigantea</i> extract |
| topic_facet |
Farmacia asthm calotropis gigantea compound 48/80 mast cells Plantas Medicinales Técnicas y Procedimientos de Laboratorio |
| description |
Calotropis gigantea (Linn.) R.Br. (Asclepiadaceae), commonly known as milkweed or swallow- wort, is found chiefly in wasteland throughout India. It has been reported as a traditional folkloric medicine in treatment of asthma in the Indian literature. Roots containing α-and β-amyrin are reported to possess anti-lipoxygenase activity. Hence, our objective was to evaluate the effect of the methanolic extract of Calotropis gigantea (CG) root on egg albumin induced passive paw anaphylaxis and compound 48/80 induced mast cell degranulation in rats. CG were given at doses of 100, 200, 400 mg/kg, p.o., to rats. We found that CG significantly increases percentage inhibition of paw edema volume at all doses but shows significant percentage protection of the mast cells at 400 mg/kg. p.o., to rats. Hence, the present investigation confirm the use of CG as anti-anaphylactic and mast cell stabilizing in treatment of asthma. |
| format |
Articulo Comunicacion |
| author |
Bulani, Vipin D. Ghaisas, Mahesh M. Kumar, Dinesh Sarda, Anupama P. Bhamre, Sachin S. |
| author_facet |
Bulani, Vipin D. Ghaisas, Mahesh M. Kumar, Dinesh Sarda, Anupama P. Bhamre, Sachin S. |
| author_sort |
Bulani, Vipin D. |
| title |
Anti-anaphylactic and mast cell stabilizing effect of <i>Calotropis gigantea</i> extract |
| title_short |
Anti-anaphylactic and mast cell stabilizing effect of <i>Calotropis gigantea</i> extract |
| title_full |
Anti-anaphylactic and mast cell stabilizing effect of <i>Calotropis gigantea</i> extract |
| title_fullStr |
Anti-anaphylactic and mast cell stabilizing effect of <i>Calotropis gigantea</i> extract |
| title_full_unstemmed |
Anti-anaphylactic and mast cell stabilizing effect of <i>Calotropis gigantea</i> extract |
| title_sort |
anti-anaphylactic and mast cell stabilizing effect of <i>calotropis gigantea</i> extract |
| publishDate |
2011 |
| url |
http://sedici.unlp.edu.ar/handle/10915/8146 http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_2_3.pdf |
| work_keys_str_mv |
AT bulanivipind antianaphylacticandmastcellstabilizingeffectoficalotropisgiganteaiextract AT ghaisasmaheshm antianaphylacticandmastcellstabilizingeffectoficalotropisgiganteaiextract AT kumardinesh antianaphylacticandmastcellstabilizingeffectoficalotropisgiganteaiextract AT sardaanupamap antianaphylacticandmastcellstabilizingeffectoficalotropisgiganteaiextract AT bhamresachins antianaphylacticandmastcellstabilizingeffectoficalotropisgiganteaiextract |
| bdutipo_str |
Repositorios |
| _version_ |
1764820488120434691 |