Inhibitory potential against methicillin-resistant staphylococcus aureus (MRSA) of Dolichandrone spathacea, a mangrove tree species of Malaysia

In this study, methanol extracts from the leaf and stem of Dolichandrone spathacea (L.f) K. Schum., a lesser-known local mangrove tree species, was evaluated using disc diffusion and minimum inhibitory concentration (MIC) value determination assays against six strains of local MRSA clinical isolat...

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Autores principales: Saiful, Azmi J., Mastura, Mohtar, Mazurah, Mohamed I., Nuziah, Hashim
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
dolichandrone spathacea; inhibitory potential; methicillin-resistant staphylococcus aureus (MRSA); phytochemical screening
Extractos Vegetales
Técnicas de Química Analítica
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8145
http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_2_2.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8145
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
dolichandrone spathacea; inhibitory potential; methicillin-resistant staphylococcus aureus (MRSA); phytochemical screening
Extractos Vegetales
Técnicas de Química Analítica
spellingShingle Farmacia
dolichandrone spathacea; inhibitory potential; methicillin-resistant staphylococcus aureus (MRSA); phytochemical screening
Extractos Vegetales
Técnicas de Química Analítica
Saiful, Azmi J.
Mastura, Mohtar
Mazurah, Mohamed I.
Nuziah, Hashim
Inhibitory potential against methicillin-resistant staphylococcus aureus (MRSA) of Dolichandrone spathacea, a mangrove tree species of Malaysia
topic_facet Farmacia
dolichandrone spathacea; inhibitory potential; methicillin-resistant staphylococcus aureus (MRSA); phytochemical screening
Extractos Vegetales
Técnicas de Química Analítica
description In this study, methanol extracts from the leaf and stem of Dolichandrone spathacea (L.f) K. Schum., a lesser-known local mangrove tree species, was evaluated using disc diffusion and minimum inhibitory concentration (MIC) value determination assays against six strains of local MRSA clinical isolates and one ATCC MRSA reference strain. The stem extract exhibited a higher zone of inhibition as compared with the leaf extract against the tested isolates. Further qualitative evaluation of the stem extract showed MIC values between 1.25 to 1.88 mg/ml against three selected MRSA clinical isolates. Phytochemical screening revealed that the triterpene and saponin compounds might be responsible for the better inhibitory activity from the stem extract as compared to the leaf extract. This study is the first report of the phytochemical screening and the inhibitory activity of D. spathacea leaves and stems methanolic extracts against MRSA clinical isolates.
format Articulo
Comunicacion
author Saiful, Azmi J.
Mastura, Mohtar
Mazurah, Mohamed I.
Nuziah, Hashim
author_facet Saiful, Azmi J.
Mastura, Mohtar
Mazurah, Mohamed I.
Nuziah, Hashim
author_sort Saiful, Azmi J.
title Inhibitory potential against methicillin-resistant staphylococcus aureus (MRSA) of Dolichandrone spathacea, a mangrove tree species of Malaysia
title_short Inhibitory potential against methicillin-resistant staphylococcus aureus (MRSA) of Dolichandrone spathacea, a mangrove tree species of Malaysia
title_full Inhibitory potential against methicillin-resistant staphylococcus aureus (MRSA) of Dolichandrone spathacea, a mangrove tree species of Malaysia
title_fullStr Inhibitory potential against methicillin-resistant staphylococcus aureus (MRSA) of Dolichandrone spathacea, a mangrove tree species of Malaysia
title_full_unstemmed Inhibitory potential against methicillin-resistant staphylococcus aureus (MRSA) of Dolichandrone spathacea, a mangrove tree species of Malaysia
title_sort inhibitory potential against methicillin-resistant staphylococcus aureus (mrsa) of dolichandrone spathacea, a mangrove tree species of malaysia
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8145
http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_2_2.pdf
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