Gastroretentive drug delivery system of captopril and hydrochlorothiazide bilayer tablet: formulation, optimization and in vivo evaluation

The purpose of the present study was to develop and optimize floating-bioadhesive bilayer gastroretentive drug delivery system (GRDDS) exhibiting a unique combination of floatation and bioadhesion to prolong residence in the stomach using captopril (CP) and hydrochlorothiazide (HCTZ) as a model d...

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Detalles Bibliográficos
Autores principales: Wadekar, Sharadchandra B., Kshirsagar, Sanjay J., Gupta, Sunil R., Shewale, Nitin S., Bhalekar, Mangesh R., Supe, Santosh
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
captopril; factorial design; floating-bioadhesive tablet; hydrochlorothiazide; X-ray studies
Sistemas de Liberación de Medicamentos
Interacciones de Drogas
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8140
http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_1_16.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8140
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
captopril; factorial design; floating-bioadhesive tablet; hydrochlorothiazide; X-ray studies
Sistemas de Liberación de Medicamentos
Interacciones de Drogas
spellingShingle Farmacia
captopril; factorial design; floating-bioadhesive tablet; hydrochlorothiazide; X-ray studies
Sistemas de Liberación de Medicamentos
Interacciones de Drogas
Wadekar, Sharadchandra B.
Kshirsagar, Sanjay J.
Gupta, Sunil R.
Shewale, Nitin S.
Bhalekar, Mangesh R.
Supe, Santosh
Gastroretentive drug delivery system of captopril and hydrochlorothiazide bilayer tablet: formulation, optimization and in vivo evaluation
topic_facet Farmacia
captopril; factorial design; floating-bioadhesive tablet; hydrochlorothiazide; X-ray studies
Sistemas de Liberación de Medicamentos
Interacciones de Drogas
description The purpose of the present study was to develop and optimize floating-bioadhesive bilayer gastroretentive drug delivery system (GRDDS) exhibiting a unique combination of floatation and bioadhesion to prolong residence in the stomach using captopril (CP) and hydrochlorothiazide (HCTZ) as a model drug. Captopril being unstable in intestinal pH and HCTZ has specific absorption from duodenum and the first part of the jejunum and to a small extent in the stomach are suitable candidate for GRDDS. 32 factorial design was employed in formulating and optimizing the GRDDS for bilayer tablet of CP and HCTZ matrix tablet. The main effect and interaction terms were quantitatively evaluated using a mathematical model. The gastroretentive ability of the tablets was evaluated by X-radiographic studies in healthy human volunteer. The tablet releases CP and HCTZ for extended period up to 24 h in controlled manner. The predicted values agreed well with the experimental values and the results demonstrate the feasibility of the optimization methodology in the development of GRDDS. The tablet was buoyant for up to 16 h in human stomach. Development of once a day gastroretentive formulation of CP and HCTZ improves the patience compliance and bioavailability of drugs.
format Articulo
Articulo
author Wadekar, Sharadchandra B.
Kshirsagar, Sanjay J.
Gupta, Sunil R.
Shewale, Nitin S.
Bhalekar, Mangesh R.
Supe, Santosh
author_facet Wadekar, Sharadchandra B.
Kshirsagar, Sanjay J.
Gupta, Sunil R.
Shewale, Nitin S.
Bhalekar, Mangesh R.
Supe, Santosh
author_sort Wadekar, Sharadchandra B.
title Gastroretentive drug delivery system of captopril and hydrochlorothiazide bilayer tablet: formulation, optimization and in vivo evaluation
title_short Gastroretentive drug delivery system of captopril and hydrochlorothiazide bilayer tablet: formulation, optimization and in vivo evaluation
title_full Gastroretentive drug delivery system of captopril and hydrochlorothiazide bilayer tablet: formulation, optimization and in vivo evaluation
title_fullStr Gastroretentive drug delivery system of captopril and hydrochlorothiazide bilayer tablet: formulation, optimization and in vivo evaluation
title_full_unstemmed Gastroretentive drug delivery system of captopril and hydrochlorothiazide bilayer tablet: formulation, optimization and in vivo evaluation
title_sort gastroretentive drug delivery system of captopril and hydrochlorothiazide bilayer tablet: formulation, optimization and in vivo evaluation
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8140
http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_1_16.pdf
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AT guptasunilr gastroretentivedrugdeliverysystemofcaptoprilandhydrochlorothiazidebilayertabletformulationoptimizationandinvivoevaluation
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bdutipo_str Repositorios
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