Spectrophotometric analysis of Cabergoline in pharmaceutical preparations

Cabergoline (CAB) is a synthetic ergoline dopamine agonist with high affinity to D<SUB>2</SUB> receptors, thus used for the treatment of Parkinson's patients and hyperprolactinemia disorders. In this study, simple, fast, reliable and validated UV-VIS and 2nd order derivative spectro...

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Detalles Bibliográficos
Autores principales:	Salman, Demet, Dogan, Aysegul, Basci, Nursabah E.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia Técnicas de Química Analítica Receptores de Dopamina D2 Cabergoline; derivative spectrophotometry; direct analysis; tablet; UV-VIS spectrophotometry
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8137 http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_1_13.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8137
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Técnicas de Química Analítica Receptores de Dopamina D2 Cabergoline; derivative spectrophotometry; direct analysis; tablet; UV-VIS spectrophotometry
spellingShingle	Farmacia Técnicas de Química Analítica Receptores de Dopamina D2 Cabergoline; derivative spectrophotometry; direct analysis; tablet; UV-VIS spectrophotometry Salman, Demet Dogan, Aysegul Basci, Nursabah E. Spectrophotometric analysis of Cabergoline in pharmaceutical preparations
topic_facet	Farmacia Técnicas de Química Analítica Receptores de Dopamina D2 Cabergoline; derivative spectrophotometry; direct analysis; tablet; UV-VIS spectrophotometry
description	Cabergoline (CAB) is a synthetic ergoline dopamine agonist with high affinity to D<SUB>2</SUB> receptors, thus used for the treatment of Parkinson's patients and hyperprolactinemia disorders. In this study, simple, fast, reliable and validated UV-VIS and 2nd order derivative spectrophotometric methods for determination of CAB in pharmaceutical preparations were developed without any previous sample preparation step. Determination of CAB was performed at 280 nm wavelength by UV-VIS spectrophotometry and in the range of 227-232 nm by 2nd order derivative spectrophotometry. Developed both spectrophotometric methods were linear over the range of CAB concentrations from 1 to 125 µg mL<SUP>-1</SUP>-. The highest relative error and relative standard deviation in within-day and day-to-day study for UV-VIS spectrophotometry were found to be 1.10% and 0.63%, respectively. The relative error and relative standard deviation in within-day and day-to-day study for 2nd order derivative spectrophotometry were not higher than 1.10% and 0.70%, respectively.
format	Articulo Articulo
author	Salman, Demet Dogan, Aysegul Basci, Nursabah E.
author_facet	Salman, Demet Dogan, Aysegul Basci, Nursabah E.
author_sort	Salman, Demet
title	Spectrophotometric analysis of Cabergoline in pharmaceutical preparations
title_short	Spectrophotometric analysis of Cabergoline in pharmaceutical preparations
title_full	Spectrophotometric analysis of Cabergoline in pharmaceutical preparations
title_fullStr	Spectrophotometric analysis of Cabergoline in pharmaceutical preparations
title_full_unstemmed	Spectrophotometric analysis of Cabergoline in pharmaceutical preparations
title_sort	spectrophotometric analysis of cabergoline in pharmaceutical preparations
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8137 http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_1_13.pdf
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bdutipo_str	Repositorios
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Spectrophotometric analysis of Cabergoline in pharmaceutical preparations

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