Formulation study of quercetin-loaded lipid-based nanocarriers obtained by hot solvent diffusion method

Lipid-based nanocarriers were prepared by hot solvent diffusion technique. Tristearin (TS) and/or castor oil were employed as oily phase, and Lutrol F68® or Solutol HS15® and lecithin were employed as surfactant and cosurfactant, respectively. The influence of the formulation variables on surface ch...

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Autores principales: Dora, Cristiana L., Silva, Luis Felipe Costa, Tagliari, Mónika P., Segatto Silva, Marcos Antonio, Lemos Senna, Elenara
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Ciencias Naturales
Paleontología
in vitro drug release; lipid-based nanocarriers; quercetin
Técnicas y Procedimientos de Laboratorio
Nanomedicina
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8135
http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_1_11.pdf
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SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8135
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Naturales
Paleontología
in vitro drug release; lipid-based nanocarriers; quercetin
Técnicas y Procedimientos de Laboratorio
Nanomedicina
spellingShingle Ciencias Naturales
Paleontología
in vitro drug release; lipid-based nanocarriers; quercetin
Técnicas y Procedimientos de Laboratorio
Nanomedicina
Dora, Cristiana L.
Silva, Luis Felipe Costa
Tagliari, Mónika P.
Segatto Silva, Marcos Antonio
Lemos Senna, Elenara
Formulation study of quercetin-loaded lipid-based nanocarriers obtained by hot solvent diffusion method
topic_facet Ciencias Naturales
Paleontología
in vitro drug release; lipid-based nanocarriers; quercetin
Técnicas y Procedimientos de Laboratorio
Nanomedicina
description Lipid-based nanocarriers were prepared by hot solvent diffusion technique. Tristearin (TS) and/or castor oil were employed as oily phase, and Lutrol F68® or Solutol HS15® and lecithin were employed as surfactant and cosurfactant, respectively. The influence of the formulation variables on surface charge and size of the nanocarriers and their ability to load and control the release of quercetin were investigated. Solid lipid nanoparticles, nanostructured lipid carriers, nanoemulsions, and microemulsions (ME) were obtained depending on the formulation composition. Querecetin (QU) entrapment efficacy was higher than 99 % for all formulations. However, drug content was greatly affected by the formulation composition. ME exhibited the highest capacity to load QU, reaching a concentration around 1,300 times higher than its aqueous solubility. QU release profiles exhibited biphasic kinetics for all formulations. However, the release rate of QU was affected by the properties of the nanocarrier.
format Articulo
Articulo
author Dora, Cristiana L.
Silva, Luis Felipe Costa
Tagliari, Mónika P.
Segatto Silva, Marcos Antonio
Lemos Senna, Elenara
author_facet Dora, Cristiana L.
Silva, Luis Felipe Costa
Tagliari, Mónika P.
Segatto Silva, Marcos Antonio
Lemos Senna, Elenara
author_sort Dora, Cristiana L.
title Formulation study of quercetin-loaded lipid-based nanocarriers obtained by hot solvent diffusion method
title_short Formulation study of quercetin-loaded lipid-based nanocarriers obtained by hot solvent diffusion method
title_full Formulation study of quercetin-loaded lipid-based nanocarriers obtained by hot solvent diffusion method
title_fullStr Formulation study of quercetin-loaded lipid-based nanocarriers obtained by hot solvent diffusion method
title_full_unstemmed Formulation study of quercetin-loaded lipid-based nanocarriers obtained by hot solvent diffusion method
title_sort formulation study of quercetin-loaded lipid-based nanocarriers obtained by hot solvent diffusion method
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8135
http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_1_11.pdf
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AT tagliarimonikap formulationstudyofquercetinloadedlipidbasednanocarriersobtainedbyhotsolventdiffusionmethod
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bdutipo_str Repositorios
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