Development and characterization of controlled release mucoadhesive tablets of captopril to increase the residence time in the gastrointestinal tract
The present investigation concerns the development of mucoadhesive tablets of captopril which were designed to prolong the gastric residence time after oral administration. Matrix tablets of captopril were formulated using different mucoadhesive polymers such as guar gum, xanthan gum, hydroxyl pr...
Guardado en:
| Autores principales: | , , |
|---|---|
| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2011
|
| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8133 http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_1_8.pdf |
| Aporte de: |
| id |
I19-R120-10915-8133 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia captopril; gastro-retentive tablet; mucoadhesive tablets; swelling index |
| spellingShingle |
Farmacia captopril; gastro-retentive tablet; mucoadhesive tablets; swelling index Dalvadi, Hitesh P. Patel, Jayavdan K. Jayakar, B. Development and characterization of controlled release mucoadhesive tablets of captopril to increase the residence time in the gastrointestinal tract |
| topic_facet |
Farmacia captopril; gastro-retentive tablet; mucoadhesive tablets; swelling index |
| description |
The present investigation concerns the development of mucoadhesive tablets of captopril
which were designed to prolong the gastric residence time after oral administration. Matrix tablets of captopril
were formulated using different mucoadhesive polymers such as guar gum, xanthan gum, hydroxyl
propyl methyl cellulose (HPMC) K4M and K15M in various ratios. The tablets were evaluated for physical
properties, content uniformity, swelling index, bioadhesive strength and in vitro drug release. Swelling
was increased as the concentration and viscosity of HPMC increases. Tablets formulated using guar gum
and xanthan gum alone were eroded faster and dissolved completely within 5-7 h, while tablet containing
HPMC remain intact and provided slow release up to 11-12 h. It was evident from the study that the formulation
F10 containing HPMC K15M and xanthan gum (1:1) exhibited maximum bioadhesive strength
of 31.59 ± 0.05 gm and in vitro drug release was found to be 91.85 % at the end of 12 h with non-fickian
diffusion mechanism. The stability studies of optimized batch showed that there was no change in bioadhesive
strength and in vitro release when stored at different temperature condition for 90 days. It was concluded
that formulation F10 shows the better bioadhesive strength and drug release. |
| format |
Articulo Articulo |
| author |
Dalvadi, Hitesh P. Patel, Jayavdan K. Jayakar, B. |
| author_facet |
Dalvadi, Hitesh P. Patel, Jayavdan K. Jayakar, B. |
| author_sort |
Dalvadi, Hitesh P. |
| title |
Development and characterization of controlled release mucoadhesive tablets of captopril to increase the residence time in the gastrointestinal tract |
| title_short |
Development and characterization of controlled release mucoadhesive tablets of captopril to increase the residence time in the gastrointestinal tract |
| title_full |
Development and characterization of controlled release mucoadhesive tablets of captopril to increase the residence time in the gastrointestinal tract |
| title_fullStr |
Development and characterization of controlled release mucoadhesive tablets of captopril to increase the residence time in the gastrointestinal tract |
| title_full_unstemmed |
Development and characterization of controlled release mucoadhesive tablets of captopril to increase the residence time in the gastrointestinal tract |
| title_sort |
development and characterization of controlled release mucoadhesive tablets of captopril to increase the residence time in the gastrointestinal tract |
| publishDate |
2011 |
| url |
http://sedici.unlp.edu.ar/handle/10915/8133 http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_1_8.pdf |
| work_keys_str_mv |
AT dalvadihiteshp developmentandcharacterizationofcontrolledreleasemucoadhesivetabletsofcaptopriltoincreasetheresidencetimeinthegastrointestinaltract AT pateljayavdank developmentandcharacterizationofcontrolledreleasemucoadhesivetabletsofcaptopriltoincreasetheresidencetimeinthegastrointestinaltract AT jayakarb developmentandcharacterizationofcontrolledreleasemucoadhesivetabletsofcaptopriltoincreasetheresidencetimeinthegastrointestinaltract |
| bdutipo_str |
Repositorios |
| _version_ |
1764820487994605569 |