Evaluation of the in vitro and in vivo antioxidant potential of whole plant extracts of Hedyotis puberula (G. Don) R. Br. ex Arn.

The total phenolic content and in vitro and in vivo antioxidant activities of the whole plants of Hedyotis puberula (G. Don) R.Br. ex Arn. were appraised. The methanol extract of the plant contained higher levels of total phenolics, tannins and flavonoids content than other solvent extracts. Extra...

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Detalles Bibliográficos
Autores principales: Joseph, Jince M., Sowndhararajan, Kandhasamy, Manian, Sellamuthu
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
antioxidant activity; flavonoids; Hedyotis puberula; phenolics
Extractos Vegetales
Técnicas de Investigación
Acciones Farmacológicas
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8132
http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_1_7.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8132
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
antioxidant activity; flavonoids; Hedyotis puberula; phenolics
Extractos Vegetales
Técnicas de Investigación
Acciones Farmacológicas
spellingShingle Farmacia
antioxidant activity; flavonoids; Hedyotis puberula; phenolics
Extractos Vegetales
Técnicas de Investigación
Acciones Farmacológicas
Joseph, Jince M.
Sowndhararajan, Kandhasamy
Manian, Sellamuthu
Evaluation of the in vitro and in vivo antioxidant potential of whole plant extracts of Hedyotis puberula (G. Don) R. Br. ex Arn.
topic_facet Farmacia
antioxidant activity; flavonoids; Hedyotis puberula; phenolics
Extractos Vegetales
Técnicas de Investigación
Acciones Farmacológicas
description The total phenolic content and in vitro and in vivo antioxidant activities of the whole plants of Hedyotis puberula (G. Don) R.Br. ex Arn. were appraised. The methanol extract of the plant contained higher levels of total phenolics, tannins and flavonoids content than other solvent extracts. Extracts were screened for antioxidant and free radical scavenging activities using various in vitro model systems. The methanol extract manifested strongest antioxidant and free radical scavenging activity. The treatment of paracetamol intoxicated wistar rats with methanol extract at the dose of 400 mg/kg, b.wt. attenuated the elevated enzyme level such as glutathione, glutathione S-transferase, glutathione peroxidase, superoxide dismutase and catalase to normal level and significantly reduced the levels of lipid peroxidation. These results showed that the methanol extract of H. puberula has significant antioxidant activity both under in vitro and in vivo conditions.
format Articulo
Articulo
author Joseph, Jince M.
Sowndhararajan, Kandhasamy
Manian, Sellamuthu
author_facet Joseph, Jince M.
Sowndhararajan, Kandhasamy
Manian, Sellamuthu
author_sort Joseph, Jince M.
title Evaluation of the in vitro and in vivo antioxidant potential of whole plant extracts of Hedyotis puberula (G. Don) R. Br. ex Arn.
title_short Evaluation of the in vitro and in vivo antioxidant potential of whole plant extracts of Hedyotis puberula (G. Don) R. Br. ex Arn.
title_full Evaluation of the in vitro and in vivo antioxidant potential of whole plant extracts of Hedyotis puberula (G. Don) R. Br. ex Arn.
title_fullStr Evaluation of the in vitro and in vivo antioxidant potential of whole plant extracts of Hedyotis puberula (G. Don) R. Br. ex Arn.
title_full_unstemmed Evaluation of the in vitro and in vivo antioxidant potential of whole plant extracts of Hedyotis puberula (G. Don) R. Br. ex Arn.
title_sort evaluation of the in vitro and in vivo antioxidant potential of whole plant extracts of hedyotis puberula (g. don) r. br. ex arn.
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8132
http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_1_7.pdf
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AT sowndhararajankandhasamy evaluationoftheinvitroandinvivoantioxidantpotentialofwholeplantextractsofhedyotispuberulagdonrbrexarn
AT maniansellamuthu evaluationoftheinvitroandinvivoantioxidantpotentialofwholeplantextractsofhedyotispuberulagdonrbrexarn
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