Influence of the selected antioxidants on the stability of the ViaSpan solution used for perfusion and organ preservation purposes

The paper presents a study on antioxidants' effects on the stability of perfusion and organ preservation liquids, in order to obtain medicinal products characterized by higher stability and efficiency. The subject of this study was a genuine ViaSpan liquid, the composition of which was modified...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Ostrózka-Cieslik, Aneta, Dolinska, Barbara, Krzysztofik, Magdalena, Caban, Artur, Ryszka, Florian, Smorag, Zdzislaw
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
accelerated stability test; antioxidants; ascorbic acid; cysteine; fumaric acid; ViaSpan
Técnicas y Procedimientos de Laboratorio
Acciones Farmacológicas
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8129
http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_1_4.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8129
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
accelerated stability test; antioxidants; ascorbic acid; cysteine; fumaric acid; ViaSpan
Técnicas y Procedimientos de Laboratorio
Acciones Farmacológicas
spellingShingle Farmacia
accelerated stability test; antioxidants; ascorbic acid; cysteine; fumaric acid; ViaSpan
Técnicas y Procedimientos de Laboratorio
Acciones Farmacológicas
Ostrózka-Cieslik, Aneta
Dolinska, Barbara
Krzysztofik, Magdalena
Caban, Artur
Ryszka, Florian
Smorag, Zdzislaw
Influence of the selected antioxidants on the stability of the ViaSpan solution used for perfusion and organ preservation purposes
topic_facet Farmacia
accelerated stability test; antioxidants; ascorbic acid; cysteine; fumaric acid; ViaSpan
Técnicas y Procedimientos de Laboratorio
Acciones Farmacológicas
description The paper presents a study on antioxidants' effects on the stability of perfusion and organ preservation liquids, in order to obtain medicinal products characterized by higher stability and efficiency. The subject of this study was a genuine ViaSpan liquid, the composition of which was modified by replacing glutathione with selected antioxidants, e.g. vitamin C, cysteine, and fumaric acid in concentrations of 0.1, 0.3, and 0.5 mmol/l. Liquid stability was evaluated using an "accelerated stability" test. Results indicate that the suggested antioxidants have a significant effect on extending the stability of the ViaSpan liquid. The best results are achieved when the genuine liquid is supplemented with ascorbic acid at a concentration of 0.45 mmol/l. An extension in the ViaSpan liquid's stability from 117 to 178 days was achieved; corresponding to a 1.5-fold increase.
format Articulo
Articulo
author Ostrózka-Cieslik, Aneta
Dolinska, Barbara
Krzysztofik, Magdalena
Caban, Artur
Ryszka, Florian
Smorag, Zdzislaw
author_facet Ostrózka-Cieslik, Aneta
Dolinska, Barbara
Krzysztofik, Magdalena
Caban, Artur
Ryszka, Florian
Smorag, Zdzislaw
author_sort Ostrózka-Cieslik, Aneta
title Influence of the selected antioxidants on the stability of the ViaSpan solution used for perfusion and organ preservation purposes
title_short Influence of the selected antioxidants on the stability of the ViaSpan solution used for perfusion and organ preservation purposes
title_full Influence of the selected antioxidants on the stability of the ViaSpan solution used for perfusion and organ preservation purposes
title_fullStr Influence of the selected antioxidants on the stability of the ViaSpan solution used for perfusion and organ preservation purposes
title_full_unstemmed Influence of the selected antioxidants on the stability of the ViaSpan solution used for perfusion and organ preservation purposes
title_sort influence of the selected antioxidants on the stability of the viaspan solution used for perfusion and organ preservation purposes
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8129
http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_1_4.pdf
work_keys_str_mv AT ostrozkacieslikaneta influenceoftheselectedantioxidantsonthestabilityoftheviaspansolutionusedforperfusionandorganpreservationpurposes
AT dolinskabarbara influenceoftheselectedantioxidantsonthestabilityoftheviaspansolutionusedforperfusionandorganpreservationpurposes
AT krzysztofikmagdalena influenceoftheselectedantioxidantsonthestabilityoftheviaspansolutionusedforperfusionandorganpreservationpurposes
AT cabanartur influenceoftheselectedantioxidantsonthestabilityoftheviaspansolutionusedforperfusionandorganpreservationpurposes
AT ryszkaflorian influenceoftheselectedantioxidantsonthestabilityoftheviaspansolutionusedforperfusionandorganpreservationpurposes
AT smoragzdzislaw influenceoftheselectedantioxidantsonthestabilityoftheviaspansolutionusedforperfusionandorganpreservationpurposes
bdutipo_str Repositorios
_version_ 1764820487944273922

Ejemplares similares