South American medicinal flora: a promising source of novel compounds with antiprotozoal activity

Native populations of South America have employed herb-based preparations for the treatment of parasite diseases. In this review, some examples of South American medicinal plants from which bioactive molecules have been isolated are presented. Results of our research related to the study of novel...

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Detalles Bibliográficos
Autores principales:	Frank, Fernanda M., Sülsen, Valeria P., Cazorla, Silvia I., Anesini, Claudia, Muschietti, Liliana V., Martino, Virginia S.
Formato:	Articulo Revision
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia antiprotozoal activity; sesquiterpene lactones; South American medicinal species Agentes Antiprotozoarios Plantas Medicinales
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8125 http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_3_1.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8125
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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia antiprotozoal activity; sesquiterpene lactones; South American medicinal species Agentes Antiprotozoarios Plantas Medicinales
spellingShingle	Farmacia antiprotozoal activity; sesquiterpene lactones; South American medicinal species Agentes Antiprotozoarios Plantas Medicinales Frank, Fernanda M. Sülsen, Valeria P. Cazorla, Silvia I. Anesini, Claudia Muschietti, Liliana V. Martino, Virginia S. South American medicinal flora: a promising source of novel compounds with antiprotozoal activity
topic_facet	Farmacia antiprotozoal activity; sesquiterpene lactones; South American medicinal species Agentes Antiprotozoarios Plantas Medicinales
description	Native populations of South America have employed herb-based preparations for the treatment of parasite diseases. In this review, some examples of South American medicinal plants from which bioactive molecules have been isolated are presented. Results of our research related to the study of novel compounds with antiprotozoal activity are also presented herein. Peruvin and psilostachyin, two sesquiterpene lactones isolated from the Argentine medicinal species Ambrosia tenuifolia, presented significative in vitro activity on Trypanosoma cruzi epimastigotes and trypomastigotes. Psilostachyin also presented in vivo activity in T. cruzi infected mice. Both compounds were also active on Leishmania spp. The results obtained suggest that psilostachyin could be considered a potential lead molecule in the development of novel trypanocidal agents.
format	Articulo Revision
author	Frank, Fernanda M. Sülsen, Valeria P. Cazorla, Silvia I. Anesini, Claudia Muschietti, Liliana V. Martino, Virginia S.
author_facet	Frank, Fernanda M. Sülsen, Valeria P. Cazorla, Silvia I. Anesini, Claudia Muschietti, Liliana V. Martino, Virginia S.
author_sort	Frank, Fernanda M.
title	South American medicinal flora: a promising source of novel compounds with antiprotozoal activity
title_short	South American medicinal flora: a promising source of novel compounds with antiprotozoal activity
title_full	South American medicinal flora: a promising source of novel compounds with antiprotozoal activity
title_fullStr	South American medicinal flora: a promising source of novel compounds with antiprotozoal activity
title_full_unstemmed	South American medicinal flora: a promising source of novel compounds with antiprotozoal activity
title_sort	south american medicinal flora: a promising source of novel compounds with antiprotozoal activity
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8125 http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_3_1.pdf
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South American medicinal flora: a promising source of novel compounds with antiprotozoal activity

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