Synthesis and anti-inflammatory activity of 2-{[3-(trifluoromethyl) phenyl] amino} N, N'-bis (aryl) pyridine-3-carboximidamide
A novel compounds of 2-{[3-(trifluoromethyl) phenyl] amino} N, N'-bis (aryl) pyridine-3-carboximidamide (PJS1-PJS6) were synthesized by condensation of niflumic acid with aromatic amines using most reactive Lewis reagent: polyphosphoric acid trimethyl silyl ester (PPSE). These compounds were ch...
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| Autores principales: | , |
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| Formato: | Articulo Comunicacion |
| Lenguaje: | Inglés |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8123 http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_2_7.pdf |
| Aporte de: |
| Sumario: | A novel compounds of 2-{[3-(trifluoromethyl) phenyl] amino} N, N'-bis (aryl) pyridine-3-carboximidamide (PJS1-PJS6) were synthesized by condensation of niflumic acid with aromatic amines using most reactive Lewis reagent: polyphosphoric acid trimethyl silyl ester (PPSE). These compounds were characterized by IR, 1H-NMR, HRMS-FAB and elemental analysis and evaluated for anti-inflammatory activity using carrageenin- induced rat paw oedema method. Compound PJS 5 showed significant activity exhibiting comparable reduction in edema. |
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