Synthesis and anti-inflammatory activity of 2-{[3-(trifluoromethyl) phenyl] amino} N, N'-bis (aryl) pyridine-3-carboximidamide

A novel compounds of 2-{[3-(trifluoromethyl) phenyl] amino} N, N'-bis (aryl) pyridine-3-carboximidamide (PJS1-PJS6) were synthesized by condensation of niflumic acid with aromatic amines using most reactive Lewis reagent: polyphosphoric acid trimethyl silyl ester (PPSE). These compounds were ch...

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Detalles Bibliográficos
Autores principales: Shirote, Pramodkumar J., Bhatia, Manish S.
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
anti-inflammatory activity; niflumic acid; polyphosphoric acid trimethyl silyl ester (PPSE)
Agentes Antiinflamatorios
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8123
http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_2_7.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8123
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
anti-inflammatory activity; niflumic acid; polyphosphoric acid trimethyl silyl ester (PPSE)
Agentes Antiinflamatorios
spellingShingle Farmacia
anti-inflammatory activity; niflumic acid; polyphosphoric acid trimethyl silyl ester (PPSE)
Agentes Antiinflamatorios
Shirote, Pramodkumar J.
Bhatia, Manish S.
Synthesis and anti-inflammatory activity of 2-{[3-(trifluoromethyl) phenyl] amino} N, N'-bis (aryl) pyridine-3-carboximidamide
topic_facet Farmacia
anti-inflammatory activity; niflumic acid; polyphosphoric acid trimethyl silyl ester (PPSE)
Agentes Antiinflamatorios
description A novel compounds of 2-{[3-(trifluoromethyl) phenyl] amino} N, N'-bis (aryl) pyridine-3-carboximidamide (PJS1-PJS6) were synthesized by condensation of niflumic acid with aromatic amines using most reactive Lewis reagent: polyphosphoric acid trimethyl silyl ester (PPSE). These compounds were characterized by IR, 1H-NMR, HRMS-FAB and elemental analysis and evaluated for anti-inflammatory activity using carrageenin- induced rat paw oedema method. Compound PJS 5 showed significant activity exhibiting comparable reduction in edema.
format Articulo
Comunicacion
author Shirote, Pramodkumar J.
Bhatia, Manish S.
author_facet Shirote, Pramodkumar J.
Bhatia, Manish S.
author_sort Shirote, Pramodkumar J.
title Synthesis and anti-inflammatory activity of 2-{[3-(trifluoromethyl) phenyl] amino} N, N'-bis (aryl) pyridine-3-carboximidamide
title_short Synthesis and anti-inflammatory activity of 2-{[3-(trifluoromethyl) phenyl] amino} N, N'-bis (aryl) pyridine-3-carboximidamide
title_full Synthesis and anti-inflammatory activity of 2-{[3-(trifluoromethyl) phenyl] amino} N, N'-bis (aryl) pyridine-3-carboximidamide
title_fullStr Synthesis and anti-inflammatory activity of 2-{[3-(trifluoromethyl) phenyl] amino} N, N'-bis (aryl) pyridine-3-carboximidamide
title_full_unstemmed Synthesis and anti-inflammatory activity of 2-{[3-(trifluoromethyl) phenyl] amino} N, N'-bis (aryl) pyridine-3-carboximidamide
title_sort synthesis and anti-inflammatory activity of 2-{[3-(trifluoromethyl) phenyl] amino} n, n'-bis (aryl) pyridine-3-carboximidamide
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8123
http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_2_7.pdf
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AT bhatiamanishs synthesisandantiinflammatoryactivityof23trifluoromethylphenylaminonnbisarylpyridine3carboximidamide
bdutipo_str Repositorios
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