In vitro study on interaction of ketotifen fumarate with metformin hydrochloride

The present study was designed to study the in vitro interaction of ketotifen fumarate and metformin hydrochloride in aqueous media at different pH values using Job’s continuous-variation analysis and Ardon’s spectrophotomeric measurement. Job’s analysis indicated the formation of 1:1 complex betwee...

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Detalles Bibliográficos
Autores principales:	Sayeed, Mohammed Aktar, Hasan, Raquibul, Rana, Sohel
Formato:	Articulo Comunicacion
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia Ardon's mehod; Job's method; ketotifen; metformin; stability constant
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8122 http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_2_6.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8122
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Ardon's mehod; Job's method; ketotifen; metformin; stability constant
spellingShingle	Farmacia Ardon's mehod; Job's method; ketotifen; metformin; stability constant Sayeed, Mohammed Aktar Hasan, Raquibul Rana, Sohel In vitro study on interaction of ketotifen fumarate with metformin hydrochloride
topic_facet	Farmacia Ardon's mehod; Job's method; ketotifen; metformin; stability constant
description	The present study was designed to study the in vitro interaction of ketotifen fumarate and metformin hydrochloride in aqueous media at different pH values using Job’s continuous-variation analysis and Ardon’s spectrophotomeric measurement. Job’s analysis indicated the formation of 1:1 complex between ketotifen fumarate and metformin hydrochloride at the studied pH values. On the other hand, the values of stability constants (between negative values and 1), as calculated from Ardon’s plot, mean that the formation of complex due to interaction between the drugs is readily dissociable. Thus the findings of the study suggest that both drugs can be safely co-administered. However, further studies involving animal models are needed to ascertain the exact nature of interaction between them in vivo.
format	Articulo Comunicacion
author	Sayeed, Mohammed Aktar Hasan, Raquibul Rana, Sohel
author_facet	Sayeed, Mohammed Aktar Hasan, Raquibul Rana, Sohel
author_sort	Sayeed, Mohammed Aktar
title	In vitro study on interaction of ketotifen fumarate with metformin hydrochloride
title_short	In vitro study on interaction of ketotifen fumarate with metformin hydrochloride
title_full	In vitro study on interaction of ketotifen fumarate with metformin hydrochloride
title_fullStr	In vitro study on interaction of ketotifen fumarate with metformin hydrochloride
title_full_unstemmed	In vitro study on interaction of ketotifen fumarate with metformin hydrochloride
title_sort	in vitro study on interaction of ketotifen fumarate with metformin hydrochloride
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8122 http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_2_6.pdf
work_keys_str_mv	AT sayeedmohammedaktar invitrostudyoninteractionofketotifenfumaratewithmetforminhydrochloride AT hasanraquibul invitrostudyoninteractionofketotifenfumaratewithmetforminhydrochloride AT ranasohel invitrostudyoninteractionofketotifenfumaratewithmetforminhydrochloride
bdutipo_str	Repositorios
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In vitro study on interaction of ketotifen fumarate with metformin hydrochloride

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