Pharmacological basis for the medicinal use of Valeriana wallichii in constipation

Valeriana wallichii D.C. (Valerianaceae) is widely used in folk medicine for the treatment of hypo-motility disorder of the gut. The aim of the present study was to scientifically rationalize its usefulness in the constipation. The V. wallichii leaves crude extract, which tested positive for the pre...

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Detalles Bibliográficos
Autores principales: Khan, Arif-ullah, Gilani, Anwarul-Hassan
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
cholinergic; constipation; spasmogenic; Valeriana wallichii
Receptores Muscarínicos
Valeriana
Estreñimiento
Extractos Vegetales
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8121
http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_2_5.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8121
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
cholinergic; constipation; spasmogenic; Valeriana wallichii
Receptores Muscarínicos
Valeriana
Estreñimiento
Extractos Vegetales
spellingShingle Farmacia
cholinergic; constipation; spasmogenic; Valeriana wallichii
Receptores Muscarínicos
Valeriana
Estreñimiento
Extractos Vegetales
Khan, Arif-ullah
Gilani, Anwarul-Hassan
Pharmacological basis for the medicinal use of Valeriana wallichii in constipation
topic_facet Farmacia
cholinergic; constipation; spasmogenic; Valeriana wallichii
Receptores Muscarínicos
Valeriana
Estreñimiento
Extractos Vegetales
description Valeriana wallichii D.C. (Valerianaceae) is widely used in folk medicine for the treatment of hypo-motility disorder of the gut. The aim of the present study was to scientifically rationalize its usefulness in the constipation. The V. wallichii leaves crude extract, which tested positive for the presence of anthraquinones, flavonoids, saponins, sterols, tannins and terpenes caused concentration-dependent (3-10 mg/mL) contractile effect in isolated guinea-pig ileum. Pretreatment of tissues with atropine (1 μM) completely abolished the stimulatory effect of V. wallichii leaves crude extract, similar to that of acetylcholine. These results indicate that the spasmogenic effect of V. wallichii is mediated possibly through the activation of muscarinic receptors, which provides sound mechanistic background for its medicinal use in constipation.
format Articulo
Comunicacion
author Khan, Arif-ullah
Gilani, Anwarul-Hassan
author_facet Khan, Arif-ullah
Gilani, Anwarul-Hassan
author_sort Khan, Arif-ullah
title Pharmacological basis for the medicinal use of Valeriana wallichii in constipation
title_short Pharmacological basis for the medicinal use of Valeriana wallichii in constipation
title_full Pharmacological basis for the medicinal use of Valeriana wallichii in constipation
title_fullStr Pharmacological basis for the medicinal use of Valeriana wallichii in constipation
title_full_unstemmed Pharmacological basis for the medicinal use of Valeriana wallichii in constipation
title_sort pharmacological basis for the medicinal use of valeriana wallichii in constipation
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8121
http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_2_5.pdf
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bdutipo_str Repositorios
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