Biodistribution in sarcoma 180-bearing mice of N-succinyl-chitosan nanoparticles for tumor targeting
In the present study, we sought to systemically evaluate the biodistribution and the tumor-accumulation of N-succinyl-chitosan nanoparticles (Suc-Chi-NPs, 200 nm in diameter) in model tumor-bearing mice and also the binding of Suc-Chi-NPs to k562 cells was evaluated by flow cytometry. In vitro studi...
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| Autores principales: | , , , , , |
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| Formato: | Articulo Comunicacion |
| Lenguaje: | Inglés |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8120 http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_2_4.pdf |
| Aporte de: |
| Sumario: | In the present study, we sought to systemically evaluate the biodistribution and the tumor-accumulation of N-succinyl-chitosan nanoparticles (Suc-Chi-NPs, 200 nm in diameter) in model tumor-bearing mice and also the binding of Suc-Chi-NPs to k562 cells was evaluated by flow cytometry. In vitro studies showed that all Suc-Chi-NPs displayed high affinity to k562 cells. After intravenous injection of Suc- Chi-NPs via the tail vein, a small amount of Suc-Chi-NPs was found in liver and spleen for 4 days, whereas a negligible quantity was detected in heart and lung. The distributed amount of Suc-Chi-NPs in blood was as a high level throughout the 4 days. The distributed amount of Suc-Chi-NPs (> 15 % of dose) was accumulated at 1 day and gradually increased in tumor, as blood circulation time increased. This result suggests that Suc-Chi-NPs accumulate passively in the tumor tissue due to the enhanced permeability and retention (EPR) effect, following intravenous administration. These findings revealed the promising potential of Suc-Chi-NPs on the basis of Suc-Chi as a carrier for cancer therapy. |
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