Biodistribution in sarcoma 180-bearing mice of N-succinyl-chitosan nanoparticles for tumor targeting

In the present study, we sought to systemically evaluate the biodistribution and the tumor-accumulation of N-succinyl-chitosan nanoparticles (Suc-Chi-NPs, 200 nm in diameter) in model tumor-bearing mice and also the binding of Suc-Chi-NPs to k562 cells was evaluated by flow cytometry. In vitro studi...

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Autores principales: Cheng, Yan, Yan, Chengyun, Gu, Jiwei, Wang, Xi, Huang, Zhan, Chen, Dawei
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
biodistribution; nanoparticles; N-succinyl-chitosan; tumor targeting
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8120
http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_2_4.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8120
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
biodistribution; nanoparticles; N-succinyl-chitosan; tumor targeting
spellingShingle Farmacia
biodistribution; nanoparticles; N-succinyl-chitosan; tumor targeting
Cheng, Yan
Yan, Chengyun
Gu, Jiwei
Wang, Xi
Huang, Zhan
Chen, Dawei
Biodistribution in sarcoma 180-bearing mice of N-succinyl-chitosan nanoparticles for tumor targeting
topic_facet Farmacia
biodistribution; nanoparticles; N-succinyl-chitosan; tumor targeting
description In the present study, we sought to systemically evaluate the biodistribution and the tumor-accumulation of N-succinyl-chitosan nanoparticles (Suc-Chi-NPs, 200 nm in diameter) in model tumor-bearing mice and also the binding of Suc-Chi-NPs to k562 cells was evaluated by flow cytometry. In vitro studies showed that all Suc-Chi-NPs displayed high affinity to k562 cells. After intravenous injection of Suc- Chi-NPs via the tail vein, a small amount of Suc-Chi-NPs was found in liver and spleen for 4 days, whereas a negligible quantity was detected in heart and lung. The distributed amount of Suc-Chi-NPs in blood was as a high level throughout the 4 days. The distributed amount of Suc-Chi-NPs (> 15 % of dose) was accumulated at 1 day and gradually increased in tumor, as blood circulation time increased. This result suggests that Suc-Chi-NPs accumulate passively in the tumor tissue due to the enhanced permeability and retention (EPR) effect, following intravenous administration. These findings revealed the promising potential of Suc-Chi-NPs on the basis of Suc-Chi as a carrier for cancer therapy.
format Articulo
Comunicacion
author Cheng, Yan
Yan, Chengyun
Gu, Jiwei
Wang, Xi
Huang, Zhan
Chen, Dawei
author_facet Cheng, Yan
Yan, Chengyun
Gu, Jiwei
Wang, Xi
Huang, Zhan
Chen, Dawei
author_sort Cheng, Yan
title Biodistribution in sarcoma 180-bearing mice of N-succinyl-chitosan nanoparticles for tumor targeting
title_short Biodistribution in sarcoma 180-bearing mice of N-succinyl-chitosan nanoparticles for tumor targeting
title_full Biodistribution in sarcoma 180-bearing mice of N-succinyl-chitosan nanoparticles for tumor targeting
title_fullStr Biodistribution in sarcoma 180-bearing mice of N-succinyl-chitosan nanoparticles for tumor targeting
title_full_unstemmed Biodistribution in sarcoma 180-bearing mice of N-succinyl-chitosan nanoparticles for tumor targeting
title_sort biodistribution in sarcoma 180-bearing mice of n-succinyl-chitosan nanoparticles for tumor targeting
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8120
http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_2_4.pdf
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