Influence of process parameters on nimesulide-loaded Poly(D,L-lactide-co-glycolide) microcapsules
Nimesulide was formulated as sustained release microcapsules using biodegradable polymer Poly(D,L-lactide-co-glycolide) (PLGA) as the release material by non-solvent addition coacervation method. The prepared microcapsules were evaluated for physico-chemical properties i.e. size analysis, morphol...
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| Autores principales: | , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8110 http://www.latamjpharm.org/resumenes/30/1/LAJOP_30_1_1_18.pdf |
| Aporte de: |
| Sumario: | Nimesulide was formulated as sustained release microcapsules using biodegradable polymer
Poly(D,L-lactide-co-glycolide) (PLGA) as the release material by non-solvent addition coacervation
method. The prepared microcapsules were evaluated for physico-chemical properties i.e. size analysis,
morphology, micromeritics, drug content, encapsulation efficiency and drug release characteristics. All
microcapsules obtained were discrete, large, free flowing and spherical in shape. The maximum encapsulation
efficiency of nimesulide was up to 81.02 ± 2.10 %. Nimesulide release from microcapsules followed
Higuchi model. Slow release of nimesulide from PLGA microcapsules over 12 h was observed. |
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